Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MTORC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
graph TD
MTORC2["MTORC2"]
MTORC2 -->|"regulates"| Cell_Death["Cell Death"]
MTORC2 -->|"regulates"| Mitoxyperilysis["Mitoxyperilysis"]
MTORC2 -->|"activates"| AKT["AKT"]
MTORC2 -->|"phosphorylates"| PKC["PKC"]
MTORC2 -->|"phosphorylates"| SGK["SGK"]
MTORC2 -->|"mediates"| Cell_Growth["Cell Growth"]
MTORC2 -->|"mediates"| Cell_Proliferation["Cell Proliferation"]
MTOR["MTOR"] -->|"component_of"| MTORC2
GROWTH_FACTOR_RECEPTORS["GROWTH FACTOR RECEPTORS"] -->|"activates"| MTORC2
G_PROTEIN_COUPLED_RECEPTORS["G-PROTEIN COUPLED RECEPTORS"] -->|"activates"| MTORC2
Anabolic_Signals["Anabolic Signals"] -->|"activates"| MTORC2
RPL26["RPL26"] -->|"activates"| MTORC2
Nutrient_Limitation["Nutrient Limitation"] -->|"modulates"| MTORC2
GPCR["GPCR"] -->|"activates"| MTORC2| Target | Relation | Type | Str |
|---|---|---|---|
| Cell Death | regulates | process | 0.95 |
| Mitoxyperilysis | regulates | process | 0.95 |
| AKT | phosphorylates | protein | 0.90 |
| PKC | phosphorylates | protein | 0.90 |
| SGK | phosphorylates | protein | 0.90 |
| Cell Growth | mediates | process | 0.90 |
| Cell Proliferation | mediates | process | 0.90 |
| Cell Survival | mediates | process | 0.90 |
| AKT | activates | protein | 0.87 |
| Metabolic Reprogramming | mediates | process | 0.80 |
| MITOXYPERIOSIS | regulates | phenotype | 0.72 |
| PKC | activates | protein | 0.72 |
| SGK | activates | protein | 0.72 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MTOR | component_of | gene | 0.95 |
| GROWTH FACTOR RECEPTORS | activates | receptor | 0.85 |
| G-PROTEIN COUPLED RECEPTORS | activates | receptor | 0.85 |
| Anabolic Signals | activates | process | 0.85 |
| FLRT2 | regulates | gene | 0.80 |
| Nutrient Limitation | modulates | process | 0.75 |
| GROWTH_FACTOR_RECEPTORS | activates | protein | 0.64 |
| GPCR | activates | protein | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||