Neuritic Plaques

Understanding Entity Pages

This page aggregates everything SciDEX knows about Neuritic Plaques: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Neuritic plaques (also known as senile plaques) are hallmark pathological lesions found in the brains of individuals with Alzheimer disease and other neurodegenerative disorders. These extracellular deposits consist of aggregated amyloid-beta (Aβ) peptides surrounded by dystrophic neurites, activate

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flowchart TD
    Neuritic_Plaques{{"Neuritic Plaques"}}
    Alzheimer_Disease("Alzheimer Disease")
    Neuritic_Plaques -->|"associated with"| Alzheimer_Disease
    Alzheimer_s_Disease("Alzheimer's Disease")
    Neuritic_Plaques -->|"biomarker for"| Alzheimer_s_Disease
    AD_Neuropathologic_Change("AD Neuropathologic Change")
    Neuritic_Plaques -->|"component of"| AD_Neuropathologic_Change
    BETA_AMYLOID(["BETA-AMYLOID"])
    BETA_AMYLOID -->|"component of"| Neuritic_Plaques
    Extracellular_Amyloid_beta_Deposition("Extracellular Amyloid-beta Deposition")
    Extracellular_Amyloid_beta_Deposition -->|"causes"| Neuritic_Plaques
    Amyloid_Beta_Peptide("Amyloid-Beta Peptide")
    Amyloid_Beta_Peptide -->|"causes"| Neuritic_Plaques
    Amyloid_Beta(["Amyloid Beta"])
    Amyloid_Beta -->|"involved in"| Neuritic_Plaques

    style Neuritic_Plaques fill:#4a148c,stroke:#4fc3f7,stroke-width:3px,color:#fff