gene

CASS4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASS4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

149Connections

0Hypotheses

1Analyses

50Outgoing

44Incoming

0Experiments

2Debates

Summary

Page for CASS4 — Cas Scaffold Protein Family Member 4

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🧬 Gene Info

Gene Symbol	CASS4
Full Name	Cas Scaffold Protein Family Member 4
Protein Family	CAS family (CT10 Regulated Inositol Polyphosphate 4-phosphatase Type I)
Protein Type	Scaffold Protein
Function	CASS4 participates in cellular processes
Primary Expression	neurons and immune cells
Subcellular Localization	Cytoplasmic, associated with focal adhesions
Molecular Weight	49 kDa
Amino Acids	442 aa
Pathways	PI3K
UniProt ID	Q9H6S3
GeneCards	CASS4
Human Protein Atlas	CASS4
Cell Adhesion Signaling	CASS4 localizes to focal adhesions and regulates integrin-mediated signaling pathways.
Tyrosine Kinase Signaling	Interacts with Src family kinases and other signaling molecules.
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Autoimmune, Cancer
Interactions	ABCA7, ALZHEIMER, ALZHEIMER'S DISEASE, APOE, App, BIN1
KG Connections	149 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CASS4 — AlphaFold Q9H6S3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CASS4 — Cas Scaffold Protein Family Member 4

gene · 768 words

→

CASS4 Protein

protein · 752 words

→

Pathway Diagram

graph TD
    CASS4["CASS4"]
    Ms{"Ms"}
    CASS4 -->|"associated_with"| Ms
    Als{"Als"}
    CASS4 -->|"associated_with"| Als
    Alzheimer{"Alzheimer"}
    CASS4 -->|"associated_with"| Alzheimer
    CD33["CD33"]
    CASS4 -->|"associated_with"| CD33
    NME8["NME8"]
    CASS4 -->|"associated_with"| NME8
    ALZHEIMER["ALZHEIMER"]
    CASS4 -->|"associated_with"| ALZHEIMER
    BIN1["BIN1"]
    CASS4 -->|"associated_with"| BIN1
    CD2AP["CD2AP"]
    CASS4 -->|"associated_with"| CD2AP
    INPP5D["INPP5D"]
    CASS4 -->|"associated_with"| INPP5D
    EPHA1["EPHA1"]
    CASS4 -->|"associated_with"| EPHA1
    CLU["CLU"]
    CASS4 -->|"associated_with"| CLU
    CELF1["CELF1"]
    CASS4 -->|"associated_with"| CELF1
    AND["AND"]
    CASS4 -->|"associated_with"| AND
    GENES["GENES"]
    CASS4 -->|"associated_with"| GENES
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    CASS4 -->|"associated_with"| ALZHEIMER_S_DISEASE

Outgoing (105)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CASS4	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Neural Inflammation	associated_with	process	0.85
microglial activation	involved_in	process	0.75
Alzheimer disease	risk_factor_for	disease	0.70
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Autoimmune	associated_with	disease	0.65
ALS	activates	disease	0.65
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
Cancer	associated_with	disease	0.65
ALS	associated_with	disease	0.65
ALZHEIMER	activates	gene	0.60
Microglia	associated_with	cell_type	0.60
RNA	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
LNCRNA	activates	gene	0.60
Lipid Metabolism	associated_with	pathway	0.60
MICROGLIA	associated_with	gene	0.60
Immune Response	associated_with	pathway	0.60
Monocyte	associated_with	cell_type	0.60
SRC	interacts_with	protein	0.60
CHRNE	associated_with	gene	0.60
APOE	associated_with	gene	0.60
SPI1	associated_with	gene	0.60
EPHA1	activates	gene	0.60
CLU	activates	gene	0.60
BIN1	activates	gene	0.60
CD33	activates	gene	0.60
CD2AP	activates	gene	0.60
AURKA	associated_with	gene	0.60
ZCWPW1	activates	gene	0.60
FERMT2	activates	gene	0.60
CELF1	activates	gene	0.60
cell proliferation	involved_in	process	0.60
cell survival	involved_in	process	0.60
cell migration	involved_in	process	0.60
integrin signaling	involved_in	process	0.60
neuritic plaques	involved_in	process	0.60
neurofibrillary tangles	involved_in	process	0.60
synaptic connections	involved_in	process	0.60
ALZHEIMER	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
HLA	associated_with	gene	0.60
App	activates	protein	0.60
Ras	associated_with	protein	0.60
App	associated_with	protein	0.60

Incoming (44)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CASS4	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
ZCWPW1	activates	gene	0.60
FERMT2	activates	gene	0.60
MS4A6A	associated_with	gene	0.60
ABCA7	activates	gene	0.60
CELF1	activates	gene	0.60
ABCA7	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
CR1	associated_with	gene	0.60
PLD3	associated_with	gene	0.60
GENES	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
RNA	activates	gene	0.60
TREM2	associated_with	gene	0.60
RNA	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CHRNE	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
APOE	activates	gene	0.60
CD2AP	activates	gene	0.60
EPHA1	activates	gene	0.60
CLU	activates	gene	0.60
BIN1	activates	gene	0.60
AURKA	associated_with	gene	0.60
PTK2B	activates	gene	0.60
GENES	associated_with	gene	0.60
APOE Ε4	associated_with	gene	0.60
APOE	associated_with	gene	0.60
SPI1	associated_with	gene	0.60
CD33	associated_with	gene	0.60
PPAR	activates	gene	0.60
SRC	associated_with	gene	0.60
ABCA7	interacts_with	gene	0.60
LNCRNA	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
BIN1	interacts_with	gene	0.60
CASS2	interacts_with	gene	0.50
CD33	activates	gene	0.50
late	activates	disease	0.50
APOE	co_expressed_with	gene	0.50
AURKA	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Statistical Fine-Mapping of AD GWAS Loci to Identify Causal Variants

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.380

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Can Bayesian fine-mapping of the top 25 AD GWAS loci identify credible sets of c

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

Does fine-mapping to median 3-variant credible sets provide sufficient resolutio

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Related Research

Hypotheses and analyses mentioning CASS4 in their description or question text

No additional research found