gene

CASS4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASS4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

155Connections
0Hypotheses
0Analyses
50Outgoing
46Incoming

Summary

Page for CASS4 — Cas Scaffold Protein Family Member 4

View on Wiki →

🧬 Gene Info
Gene SymbolCASS4
Full NameCas Scaffold Protein Family Member 4
Protein FamilyCAS family (CT10 Regulated Inositol Polyphosphate 4-phosphatase Type I)
Protein TypeScaffold Protein
FunctionCASS4 participates in cellular processes
Primary Expressionneurons and immune cells
Subcellular LocalizationCytoplasmic, associated with focal adhesions
Molecular Weight49 kDa
Amino Acids442 aa
PathwaysPI3K
UniProt IDQ9H6S3
GeneCardsCASS4
Human Protein AtlasCASS4
Cell Adhesion SignalingCASS4 localizes to focal adhesions and regulates integrin-mediated signaling pathways.
Tyrosine Kinase SignalingInteracts with Src family kinases and other signaling molecules.
Associated DiseasesALS, Alzheimer, Alzheimer's disease, Autoimmune, Cancer
InteractionsEPHA1, CLU, BIN1, CD33, CD2AP, APOE
KG Connections155 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: CASS4 — AlphaFold Q9H6S3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

CASS4 — Cas Scaffold Protein Family Member 4

gene · 768 words

CELF1 Gene

gene · 964 words

CASS4 Protein

protein · 752 words

SLC24A4 Gene - Solute Carrier Family 24 Member 4

gene · 594 words

Proteins

index · 296 words

Genes

index · 271 words

Pathway Diagram

graph TD
    CASS4["CASS4"]
    Ms{"Ms"}
    CASS4 -->|"associated_with"| Ms
    Als{"Als"}
    CASS4 -->|"associated_with"| Als
    Alzheimer{"Alzheimer"}
    CASS4 -->|"associated_with"| Alzheimer
    CD33["CD33"]
    CASS4 -->|"associated_with"| CD33
    NME8["NME8"]
    CASS4 -->|"associated_with"| NME8
    ALZHEIMER["ALZHEIMER"]
    CASS4 -->|"associated_with"| ALZHEIMER
    BIN1["BIN1"]
    CASS4 -->|"associated_with"| BIN1
    CD2AP["CD2AP"]
    CASS4 -->|"associated_with"| CD2AP
    INPP5D["INPP5D"]
    CASS4 -->|"associated_with"| INPP5D
    EPHA1["EPHA1"]
    CASS4 -->|"associated_with"| EPHA1
    CLU["CLU"]
    CASS4 -->|"associated_with"| CLU
    CELF1["CELF1"]
    CASS4 -->|"associated_with"| CELF1
    AND["AND"]
    CASS4 -->|"associated_with"| AND
    GENES["GENES"]
    CASS4 -->|"associated_with"| GENES
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    CASS4 -->|"associated_with"| ALZHEIMER_S_DISEASE

Outgoing (109)

TargetRelationTypeStr
ds-83b31ef18d49provides_data_fordataset1.00
Neural Inflammationassociated_withprocess0.85
microglial activationinvolved_inprocess0.75
Msassociated_withdisease0.65
Alsassociated_withdisease0.65

Incoming (46)

SourceRelationTypeStr
ds-83b31ef18d49data_indataset1.00
PLD3associated_withgene0.60
ABCA7associated_withgene0.60
SORL1associated_withgene0.60
PICALMassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found