protein

optineurin-protein

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about optineurin-protein: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Incoming

0Experiments

0Debates

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🔬 Protein Info

Gene Symbol	OPTINEURIN
Aliases	optineurin-protein
Protein Type	Protein
Function	is a 66 kDa ubiquitin-binding protein encoded by the OPTN gene [@minegishi2013]
UniProt ID	Search UniProt
GeneCards	OPTINEURIN
Human Protein Atlas	OPTINEURIN
Associated Diseases	Tumor, Parkinson, ALS, Frontotemporal Dementia, Dementia, Neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: optineurin-protein — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    OPTINEURIN["OPTINEURIN"]
    ULK1["ULK1"]
    OPTINEURIN -->|"associated_with"| ULK1
    DISC1["DISC1"]
    OPTINEURIN -->|"interacts_with"| DISC1
    CATALASE["CATALASE"]
    OPTINEURIN -->|"interacts_with"| CATALASE
    SNCAIP["SNCAIP"]
    OPTINEURIN -->|"co_discussed"| SNCAIP
    FOXO3["FOXO3"]
    OPTINEURIN -->|"activates"| FOXO3
    DNA["DNA"]
    OPTINEURIN -->|"interacts_with"| DNA
    AMPK["AMPK"]
    OPTINEURIN -->|"interacts_with"| AMPK
    TOMM20["TOMM20"]
    OPTINEURIN -->|"activates"| TOMM20
    GENES["GENES"]
    OPTINEURIN -->|"activates"| GENES
    SMCR8["SMCR8"]
    OPTINEURIN -->|"interacts_with"| SMCR8
    NRF2["NRF2"]
    OPTINEURIN -->|"associated_with"| NRF2
    UBIQUITIN["UBIQUITIN"]
    OPTINEURIN -->|"associated_with"| UBIQUITIN
    style OPTINEURIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style ULK1 fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0
    style DISC1 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style CATALASE fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style SNCAIP fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style FOXO3 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style DNA fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style AMPK fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style TOMM20 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style GENES fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style SMCR8 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style NRF2 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style UBIQUITIN fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning optineurin-protein in their description or question text

No additional research found