concept

BORTEZOMIB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BORTEZOMIB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

26Connections

0Hypotheses

1Analyses

19Outgoing

7Incoming

0Experiments

1Debates

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💡 Concept Info

Name	BORTEZOMIB
Key Genes/Proteins	HDAC1, HDAC3, NLRP3, STAT3, TFEB
Related Diseases	AUTOPHAGY, INTERLEUKIN, NEUROPATHY, PROTEOSTASIS, TUMOR GROWTH

Pathway Diagram

graph TD
    BORTEZOMIB[BORTEZOMIB]
    BORTEZOMIB -->|causes| Chemotherapy_Induced_Periphera[Chemotherapy-Induced Peripheral Neuropathy]
    BORTEZOMIB -->|inhibits| TFEB[TFEB]
    BORTEZOMIB -->|causes| cognitive_impairment[cognitive impairment]
    BORTEZOMIB -->|activates| microglia[microglia]
    BORTEZOMIB -->|causes| MICROGLIA[MICROGLIA]
    HDAC1[HDAC1] -->|activates| BORTEZOMIB

Outgoing (19)

Target	Relation	Type	Str
Chemotherapy-Induced Peripheral Neuropathy	causes	disease	0.95
peripheral neuropathy	causes	phenotype	0.90
cognitive impairment	causes	disease	0.70
microglia	activates	cell_type	0.70
TFEB	inhibits	protein	0.70
MICROGLIA	causes	cell_type	0.65
HDAC3	associated_with	gene	0.50
NLRP3	associated_with	gene	0.50
HDAC1	associated_with	gene	0.50
CISPLATIN	associated_with	drug	0.45
VINCRISTINE	associated_with	drug	0.45
TFEB	associated_with	gene	0.45
STAT3	associated_with	gene	0.45
NEUROPATHY	associated_with	disease	0.45
AUTOPHAGY	associated_with	phenotype	0.45
MICROGLIA	associated_with	cell_type	0.45
INTERLEUKIN	associated_with	phenotype	0.45
OXALIPLATIN	associated_with	drug	0.45
PACLITAXEL	associated_with	drug	0.45

Incoming (7)

Source	Relation	Type	Str
HDAC1	activates	gene	0.65
PROTEOSTASIS	associated_with	phenotype	0.50
TUMOR GROWTH	associated_with	phenotype	0.50
OXALIPLATIN	associated_with	drug	0.45
PACLITAXEL	associated_with	drug	0.45
VINCRISTINE	associated_with	drug	0.45
AUTOPHAGY	associated_with	phenotype	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning BORTEZOMIB in their description or question text

No additional research found