concept

POOR PROGNOSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about POOR PROGNOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

1Analyses

0Outgoing

19Incoming

0Experiments

1Debates

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💡 Concept Info

Name	POOR PROGNOSIS

Pathway Diagram

graph TD
    POOR_PROGNOSIS[POOR PROGNOSIS]
    Her2_Amplification[Her2 Amplification] -->|correlates_with| POOR_PROGNOSIS
    Clec2_Klrb1_Axis[Clec2-Klrb1 Axis] -->|correlates_with| POOR_PROGNOSIS
    TP53_mutations[TP53 mutations] -->|causes| POOR_PROGNOSIS
    HER2_Amplification[HER2 Amplification] -->|correlates_with| POOR_PROGNOSIS
    High_Risk_MRG_Expression[High-Risk MRG Expression] -->|risk_factor_for| POOR_PROGNOSIS

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (19)

Source	Relation	Type	Str
Glioblastoma Multiforme	associated_with	disease	0.95
Her2 Amplification	correlates_with	biomarker	0.95
Clec2-Klrb1 Axis	correlates_with	mechanism	0.93
TP53 mutations	causes	gene	0.92
HER2 Amplification	correlates_with	biomarker	0.92
PI3K/AKT/mTOR Pathway	associated_with	pathway	0.90
CENPN	associated_with	gene	0.90
TMX2	associated_with	gene	0.90
High-Risk MRG Expression	risk_factor_for	biomarker	0.89
COMPLEMENT GENES	associated_with	gene	0.85
Complement Gene Overexpression	associated_with	biomarker	0.85
IGF2BP2	associated_with	gene	0.85
KLF7	associated_with	gene	0.82
CTPS1	associated_with	gene	0.80
TKT	associated_with	gene	0.80
TIGAR	associated_with	gene	0.80
BRAF mutation	associated_with	phenotype	0.80
Plasma Cells	associated_with	cell_type	0.80
human CD47	biomarker_for	protein	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do synthetic EVs achieve brain-specific targeting while avoiding reticuloend

drug delivery | 2026-04-15 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

All participants identified brain delivery as a critical barrier, but no mechani

closed · Rounds: 4 · Score: 0.50 · 2026-04-16

Related Research

Hypotheses and analyses mentioning POOR PROGNOSIS in their description or question text

No additional research found