Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about tmx2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | TMX2 |
| Protein Type | Gene |
| Function | The protein's topology places its redox-active domain in the ER lumen, where it can interact with other ER-resident proteins involved in disulfide bond formation and protein folding. |
| Molecular Weight | 32 kDa |
| Pathways | Autophagy, Oxidative Stress, Mitophagy, CRISPR-Cas, autophagy pathway |
| GeneCards | TMX2 |
| Human Protein Atlas | TMX2 |
| Associated Diseases | Hepatocellular Carcinoma, Poor Prognosis |
| Interactions | Proteins, GAIN, PRKN, VDAC2, TFEB |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TMX2["TMX2"]
TMX2 -->|"promotes"| macroautophagy["macroautophagy"]
TMX2 -->|"promotes_nuclear_import_of"| TFEB["TFEB"]
TMX2 -->|"modulates"| KPNB1["KPNB1"]
TMX2 -->|"promotes"| hepatocellular_carcinoma["hepatocellular carcinoma"]
TMX2 -->|"interacts"| VDAC3["VDAC3"]
TMX2 -->|"promotes"| mitophagy["mitophagy"]
oxidative_stress["oxidative stress"] -->|"regulates"| TMX2
Oxidative_Stress["Oxidative Stress"] -->|"upregulates"| TMX2
MITOPHAGY["MITOPHAGY"] -->|"activates"| TMX2
MITOCHONDRIA["MITOCHONDRIA"] -->|"interacts"| TMX2
AUTOPHAGY["AUTOPHAGY"] -->|"activates"| TMX2
TFEB -->|"activates"| TMX2
GENES["GENES"] -->|"activates"| TMX2| Target | Relation | Type | Str |
|---|---|---|---|
| Autophagy | activates | process | 0.50 |
| mitophagy | activates | pathway | 0.50 |
| CARCINOMA | activates | disease | 0.50 |
| HEPATOCELLULAR CARCINOMA | activates | disease | 0.50 |
| Proteins | activates | protein | 0.50 |
| GAIN | activates | gene | 0.50 |
| MITOCHONDRIA | activates | cell_type | 0.50 |
| PRKN | activates | gene | 0.50 |
| VDAC2 | activates | protein | 0.50 |
| oxidative stress | activates | phenotype | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TFEB | activates | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||