Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about synapse elimination: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| CLEC7A | regulates | gene | 0.90 |
| C3 | mediates | gene | 0.80 |
| complement activation | causes (excessive complement activation leads to neurotoxi) | mechanism | 0.75 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimina | 0.520 | neurodegeneration | How do the seven novel ALS genes functio |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.527
neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||