concept

COMPLEMENT ACTIVATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COMPLEMENT ACTIVATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

70Connections

0Hypotheses

3Analyses

24Outgoing

13Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	COMPLEMENT ACTIVATION
Key Genes/Proteins	AMYLOID, TREM2, SPI1
Related Diseases	SYNAPTIC LOSS, INFLAMMATION
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    COMPLEMENT_ACTIVATION["COMPLEMENT ACTIVATION"]
    COMPLEMENT_ACTIVATION -->|"causes"| Retinal_Ganglion_Cell_Dysfunct["Retinal Ganglion Cell Dysfunction"]
    COMPLEMENT_ACTIVATION -->|"causes"| Brain_Inflammation["Brain Inflammation"]
    COMPLEMENT_ACTIVATION -->|"activates"| MICROGLIA["MICROGLIA"]
    COMPLEMENT_ACTIVATION -->|"promotes"| Neurodegeneration["Neurodegeneration"]
    COMPLEMENT_ACTIVATION -->|"mediates"| Tissue_Destruction["Tissue Destruction"]
    COMPLEMENT_ACTIVATION -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
    NPTX2["NPTX2"] -->|"inhibits"| COMPLEMENT_ACTIVATION
    Microglia["Microglia"] -->|"upregulates"| COMPLEMENT_ACTIVATION
    C1Q["C1Q"] -->|"activates"| COMPLEMENT_ACTIVATION
    C1QA["C1QA"] -->|"regulates"| COMPLEMENT_ACTIVATION
    Progranulin["Progranulin"] -->|"regulates"| COMPLEMENT_ACTIVATION
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| COMPLEMENT_ACTIVATION
    ASTROCYTES["ASTROCYTES"] -->|"activates"| COMPLEMENT_ACTIVATION
    COMPLEMENT["COMPLEMENT"] -->|"activates"| COMPLEMENT_ACTIVATION

Outgoing (46)

Target	Relation	Type	Str
MICROGLIA	activates	cell_type	0.95
SYNAPTIC LOSS	contributes_to	entity	0.85
SYNAPTIC LOSS	causes	phenotype	0.70
NEURONS	exacerbates	cell_type	0.70
AMYLOID	causes	protein	0.70
INFLAMMATION	causes	phenotype	0.65
INFLAMMATION	implicated_in	phenotype	0.55
PHAGOCYTOSIS	activates	process	0.50
COMPLEMENT CASCADE	associated_with	pathway	0.50
CORTEX	associated_with	brain_region	0.50
AMYLOID PET	associated_with	biomarker	0.50
NLRP3 INFLAMMASOME	associated_with	pathway	0.45
RETINA	associated_with	brain_region	0.45
CHOROID PLEXUS	associated_with	brain_region	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
INFLAMMASOME	activates	protein	0.35
NEURODEGENERATION	activates	process	0.35
NEURON	activates	cell_type	0.35
NEUROINFLAMMATION	activates	process	0.35
MACROPHAGES	activates	cell_type	0.35
INFLAMMATION	activates	process	0.35
CORTEX	activates	brain_region	0.35
OXIDATIVE STRESS	activates	process	0.35
TREM2	activates	gene	0.35

Incoming (24)

Source	Relation	Type	Str
MICROGLIA	inhibits	cell_type	0.70
MICROGLIA	interacts_with	cell_type	0.65
INFLAMMATION	targets	phenotype	0.65
TREM2	interacts_with	gene	0.65
TREM2	inhibits	gene	0.65
TREM2	regulates	gene	0.65
MICROGLIA	degrades	cell_type	0.65
SPI1	interacts_with	gene	0.65
ALZHEIMER'S DISEASE	activates	disease	0.50
ASTROCYTES	activates	cell_type	0.50
COMPLEMENT	activates	protein	0.50
ALPHA-SYNUCLEIN	activates	gene	0.35
ANGIOGENESIS	activates	process	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

neuroinflammation | 2026-04-08 | 0 hypotheses

What are the specific molecular mechanisms by which C1Q components drive atheros

neuroinflammation | 2026-04-07 | 0 hypotheses

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

COMPLEMENT ACTIVATION

Understanding Entity Pages

Wiki Pages (20)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Corticobasal Syndrome (CBS)

Corticobasal Degeneration (CBD)

neuroinflammation

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

Oligodendrocytes

DIAN-TU-001 Trial (NCT01760005)

PMN310 Anti-Amyloid for AD (NCT06750432)

Glia-Neuron Crosstalk in Alzheimer's Disease

Synucleinopathies

Bepranemab (UCB0107)

Cerebral Small Vessel Disease

Neuroinflammation Across AD, PD, ALS, FTD, and HD

genetics

Synaptic Plasticity Deficits in Neurodegeneration

neurovascular-dysfunction

Oligodendrocyte and Myelin Dysfunction in Corticobasal Syndrome

Alpha-Synuclein Aggregation Pathway

DNAJC13 — DnaJ Heat Shock Protein Family Member C13

msa-pathophysiology-disease-mechanisms