Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TREATMENT RESISTANCE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | TREATMENT RESISTANCE |
Knowledge base pages for this entity
graph TD
TREATMENT_RESISTANCE["TREATMENT RESISTANCE"]
PI3K_hyperactivity["PI3K hyperactivity"] -->|"causes"| TREATMENT_RESISTANCE
PTEN_loss_of_function["PTEN loss of function"] -->|"causes"| TREATMENT_RESISTANCE
AKT_gain_of_function["AKT gain-of-function"] -->|"causes"| TREATMENT_RESISTANCE
Glioblastoma_Metabolism["Glioblastoma Metabolism"] -->|"contributes to"| TREATMENT_RESISTANCE
PI3K_AKT_mTOR["PI3K/AKT/mTOR"] -->|"causes"| TREATMENT_RESISTANCE
NF__B_Pathway["NF-kappaB Pathway"] -->|"involved_in"| TREATMENT_RESISTANCE
TGFB_Pathway["TGFB Pathway"] -->|"involved_in"| TREATMENT_RESISTANCE
Extrachromosomal_DNA["Extrachromosomal DNA"] -->|"contributes to"| TREATMENT_RESISTANCE| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| PI3K hyperactivity | causes | phenotype | 0.90 |
| PTEN loss of function | causes | phenotype | 0.90 |
| AKT gain-of-function | causes | phenotype | 0.90 |
| Glioblastoma Metabolism | contributes_to | process | 0.90 |
| Glioblastoma Multiforme | associated_with | disease | 0.90 |
| Cancer Cell Plasticity | contributes_to | process | 0.90 |
| Chronic Inflammation | causes | process | 0.90 |
| PI3K/AKT/mTOR | causes | pathway | 0.88 |
| NF-κB Pathway | involved_in | pathway | 0.85 |
| TGFB Pathway | involved_in | pathway | 0.85 |
| Extrachromosomal DNA | contributes_to | mechanism | 0.85 |
| Intratumor Heterogeneity | promotes | phenotype | 0.85 |
| Ecdna | promotes | mechanism | 0.85 |
| Bispecific Antibodies | associated_with | drug | 0.80 |
| Tumor Heterogeneity | contributes_to | phenotype | 0.80 |
| AKT | activates | gene | 0.80 |
| MTOR | activates | protein | 0.70 |
| autophagy | activates | process | 0.70 |
| blood brain barrier | activates | process | 0.70 |
| PI3K/AKT/mTOR | activates | pathway | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||