While the abstract focuses on cancer/infection contexts, the dual nature of T_PEX cells raises questions about their role in chronic neuroinflammation. These cells could either contribute to tissue damage or provide protective immunity against neurodegeneration-associated pathogens. Gap type: open_question Source paper: Precursor exhausted T cells: key to successful immunotherapy? (2020, Nature reviews. Immunology, PMID:31591533)
Landscape Summary: How do T_PEX cells contribute to neurodegeneration versus neuroprotection in chronic CNS inflammation? is a 0.75 priority gap in neuroinflammation. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
How do T_PEX cells contribute to neurodegeneration versus neuroprotection in chronic CNS inflammation? — INVOKE-2 (completed)
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