disease

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MS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5792Connections

30Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

5Debates

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Disease Info

Associated Genes	AB, ACHE, ACSL4, AD, AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID
KG Connections	550 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Ms

disease · 575 words

→

FEEMSA Study: Laryngopharyngeal Function in Neurodegenerative Diseases (NCT04706234)

clinical · 4197 words

→

Pathway Diagram

graph TD
    MS["MS"] -->|"causes"| DEMYELINATION["DEMYELINATION"]
    style DEMYELINATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    MS["MS"] -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    style NEURODEGENERATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    MS["MS"] -->|"causes"| AXONAL_DAMAGE["AXONAL_DAMAGE"]
    style AXONAL_DAMAGE fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    MS["MS"] -->|"regulates"| CNS["CNS"]
    style CNS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    MS["MS"] -->|"associated"| OXPCS["OXPCS"]
    style OXPCS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    MS["MS"] -->|"causes"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    style NEUROINFLAMMATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    MS["MS"] -->|"causes"| STING["STING"]
    style STING fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    STING_1["STING"] -->|"implicated in"| MS["MS"]
    style STING_1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    SPINK5["SPINK5"] -->|"associated"| MS["MS"]
    style SPINK5 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    STS["STS"] -->|"associated"| MS["MS"]
    style STS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    B_cells["B cells"] -->|"associated"| MS["MS"]
    style B_cells fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    INFLAMMATION_1["INFLAMMATION_1"] -->|"causes"| MS["MS"]
    style INFLAMMATION_1 fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    style MS fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (623)

Target	Relation	Type	Str
DEMYELINATION	causes	phenotype	1.00
NEURODEGENERATION	causes	phenotype	1.00
diseases-ms	has_wiki	wiki	1.00
AXONAL_DAMAGE	causes	phenotype	0.79
NEUROINFLAMMATION	causes	phenotype	0.72
CNS	regulates	brain_region	0.72
OXPCS	associated_with	protein	0.72
STING	causes	protein	0.72
neurodegeneration	associated_with	phenotype	0.72
BRAIN_ATROPHY	causes	phenotype	0.64
AXONAL_LOSS	causes	phenotype	0.64
Apoptosis	activates	pathway	0.60
Toll-Like Receptor	therapeutic_target	pathway	0.60
Necroptosis	regulates	pathway	0.60
Wnt	activates	pathway	0.60
Akt	expressed_in	pathway	0.60
Pi3K	therapeutic_target	pathway	0.60
Blood-Brain Barrier	interacts_with	pathway	0.60
Necroptosis	activates	pathway	0.60
Blood-Brain Barrier	activates	pathway	0.60
Insulin Signaling	protects_against	pathway	0.60
Sleep-Wake	associated_with	pathway	0.60
Mapk	regulates	pathway	0.60
Autophagy	inhibits	pathway	0.60
Insulin Signaling	interacts_with	pathway	0.60
Proteasome	inhibits	pathway	0.60
Pyroptosis	therapeutic_target	pathway	0.60
Jak-Stat	therapeutic_target	pathway	0.60
Nf-Κb	expressed_in	pathway	0.60
Hedgehog	activates	pathway	0.60
Ferroptosis	inhibits	pathway	0.60
Mitophagy	regulates	pathway	0.60
Hedgehog	inhibits	pathway	0.60
Glycolysis	expressed_in	pathway	0.60
Lysosomal Degradation	regulates	pathway	0.60
Mapk	inhibits	pathway	0.60
Toll-Like Receptor	associated_with	pathway	0.60
Apoptosis	protects_against	pathway	0.60
Mtor	protects_against	pathway	0.60
Autophagy	protects_against	pathway	0.60
Circadian Rhythm	activates	pathway	0.60
Oxidative Phosphorylation	contributes_to	pathway	0.60
Autophagy	biomarker_for	pathway	0.60
Blood-Brain Barrier	regulates	pathway	0.60
Apoptosis	expressed_in	pathway	0.60
Lipid Metabolism	inhibits	pathway	0.60
Synaptic Plasticity	therapeutic_target	pathway	0.60
Long-Term Potentiation	regulates	pathway	0.60
Pi3K	expressed_in	pathway	0.60
Nf-Κb	inhibits	pathway	0.60

Incoming (5169)

Source	Relation	Type	Str
diseases-ms	described_by	wiki	1.00
SPINK5	associated_with	gene	0.80
STS	associated_with	gene	0.80
STING	implicated_in	protein	0.80
B cells	associated_with	cell_type	0.80
INFLAMMATION_1	causes	phenotype	0.72
S1P receptors	implicated_in	receptor	0.70
ACSL4	associated_with	protein	0.70
S1P	implicated_in	entity	0.70
gut microbiota	associated_with	process	0.70
CD19	biomarker_for	protein	0.70
C9ORF72	inhibits	gene	0.65
P2RX7	associated_with	gene	0.65
P2X7	associated_with	gene	0.65
P2RX4	associated_with	gene	0.65
TET2	contributes_to	gene	0.65
CLOCK	interacts_with	gene	0.65
CGAS	activates	gene	0.65
P2RY1	associated_with	gene	0.65
LAMP2	associated_with	gene	0.65
RTN3	associated_with	gene	0.65
TARDBP	expressed_in	gene	0.65
DNM1L	associated_with	gene	0.65
RAB2A	associated_with	gene	0.65
VAMP7	associated_with	gene	0.65
STX17	associated_with	gene	0.65
SNAP29	associated_with	gene	0.65
GABARAPL1	associated_with	gene	0.65
RB1CC1	associated_with	gene	0.65
RAB7A	associated_with	gene	0.65
ELAVL2	therapeutic_target	gene	0.65
C1Q	therapeutic_target	gene	0.65
ABCA1	associated_with	gene	0.65
VAMP8	associated_with	gene	0.65
IGF2BP1	therapeutic_target	gene	0.65
SNAP29	regulates	gene	0.65
GABARAP	associated_with	gene	0.65
TARDBP	inhibits	gene	0.65
LONP1	therapeutic_target	gene	0.65
BDNF	therapeutic_target	gene	0.65
FUS	regulates	gene	0.65
IL1B	expressed_in	gene	0.65
JUN	expressed_in	gene	0.65
IGF2	activates	gene	0.65
IGF2R	expressed_in	gene	0.65
MCOLN1	regulates	gene	0.65
MCOLN1	activates	gene	0.65
SPHK1	activates	gene	0.65
TARDBP	activates	gene	0.65
PINK1	activates	gene	0.65

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SNCA conformer propagation across PD, DLB, and MSA	0.820	multi	Cross-disease neurodegeneration mechanis
SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso	0.734	neurodegeneration	What molecular mechanisms link elevated
EZH2-Mediated H3K27me3 Spreading in Senescent ALS Microglia	0.714	als	What are the mechanisms by which microgl
Loss of Homeostatic Epigenetic Identity Reprograms Microglia	0.650	neurodegeneration	What molecular mechanisms drive microgli
Mitochondrial ROS from complex I and cardiolipin instability	0.640	neurodegeneration	What mechanisms drive the self-amplifyin

Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention fo	0.638	neurodegeneration	CRISPR-based therapeutic approaches for
mutant FUS effects split between motor-neuron intrinsic stre	0.626	neurodegeneration	Cell-Autonomous vs Non-Cell-Autonomous M
MFN2-PACS2 Axis at MAMs Coordinates Mitophagy-ER-Phagy Sync	0.615	neurodegeneration	How do different organelle-specific auto
Cell-state stratification is required to resolve Cell-Autono	0.612	neurodegeneration	Cell-Autonomous vs Non-Cell-Autonomous M
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	m6A RNA Modification and Alpha-Synuclein
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	Cell-Autonomous vs Non-Cell-Autonomous M
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	Sex-Specific Microglial States in Amyloi
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	Genetic Aging Landscape Variants and Epi
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	DPP6 GWAS Signal: Cell-Type Regulatory N
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	Causal Sequence of TDP-43 Nuclear Cleara
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	Proteogenomic Network Hubs as Druggable
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	Biophysical Determinants Shifting FUS/TD
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	VEGF Family GWAS Signals and Cerebrovasc
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	CCL2-CCR2 Axis at NMJ: Mechanism of Sele
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	Non-Neuronal Transcriptional Changes Pre
H4: Hyperconnected Hub Status Creates Proteostatic Traffic J	0.600	neurodegeneration	Entorhinal cortex layer II vulnerability
Stratified falsifiers should govern Microglial Priming as Up	0.591	neurodegeneration	Microglial Priming as Upstream Causal No
GPC4/HSPGs Collaborate with ApoE Isoforms to Dictate Tau Con	0.583	neurodegeneration	What are the specific molecular determin
Gut-derived butyrate reprograms microglia for amyloid cleara	0.525	alzheimers	Gut-Brain Axis Therapeutics for AD
REST-like neuronal silencing programs suppress MAPT in sever	0.506	neurodegeneration	Which specific transcription factors med
Synthetic Biology Approach: Designer Mitochondrial Export Sy	0.505	neurodegeneration	Mitochondrial transfer between neurons a
Synaptic Vesicle Protein Phosphorylation Reprograms Release	0.455	neurodegeneration	Quantitative proteomics of the aging syn
Multi-Clock Ensemble Discordance as a Parkinson's Disease Pr	0.323	-	Epigenetic clocks as biomarkers for Alzh
P2Y12 Receptor-Mediated Phase Resetting of Circadian Inflamm	0.000	-	Can circadian interventions selectively
Temporal Modulation of Microglial Circadian Rhythms	0.000	-	Synaptic pruning by microglia in early A

Mentioning Analyses (3)

Scientific analyses that reference this entity

How does lncRNA-0021 achieve sequence-specific binding to mmu-miR-6361 and what

molecular neurobiology | 2026-04-25 | 28 hypotheses Top: 0.865

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.734

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.453

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (3)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple sys [PMID:9682846]	Unknown	Neuroscience letters	1998
Mutation in the alpha-synuclein gene identified in families with Parkinson's dis [PMID:9197268]	Unknown	Science (New York, N.Y.)	1997
Alpha-synuclein in Lewy bodies. [PMID:9278044]	Unknown	Nature	1997

Debates (5)

Multi-agent debates referencing this entity

How does lncRNA-0021 achieve sequence-specific binding to mmu-miR-6361 and what

closed · Rounds: 4 · Score: 0.66 · 2026-04-25

The study demonstrates that SGMS1 elevation correlates with increased Aβ and tha

closed · Rounds: 4 · Score: 0.75 · 2026-04-16

The abstract shows microglia ameliorate OxPC toxicity to neurons and oligodendro

closed · Rounds: 4 · Score: 0.68 · 2026-04-14

The abstract shows microglia ameliorate OxPC toxicity to neurons and oligodendro

closed · Rounds: 4 · Score: 0.62 · 2026-04-14

The abstract shows microglia ameliorate OxPC toxicity to neurons and oligodendro

closed · Rounds: 4 · Score: 0.92 · 2026-04-14

Related Research

Hypotheses and analyses mentioning MS in their description or question text

Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention for Severe Neurodevelo

Score: 0.638 · neurodegeneration · 2026-04-04

## Molecular Mechanism and Rationale The molecular foundation for acid-degradable lipid nanoparticle (ADP-LNP)-mediated

mutant FUS effects split between motor-neuron intrinsic stress and glial/NMJ inf

Score: 0.626 · neurodegeneration · 2026-04-28

mutant FUS effects split between motor-neuron intrinsic stress and glial/NMJ inflammatory signaling should produce a mea

MFN2-PACS2 Axis at MAMs Coordinates Mitophagy-ER-Phagy Sync

Score: 0.615 · neurodegeneration · 2026-04-21

**Molecular Mechanism and Rationale** The mitochondria-associated ER membranes (MAMs) represent specialized microdomain

Cell-state stratification is required to resolve Cell-Autonomous vs Non-Cell-Aut

Score: 0.612 · neurodegeneration · 2026-04-28

The question is likely underpowered or misleading unless analyses preserve the key strata: FUS, FUS-, ALS, NMJ. Averagin