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What determines the tissue-specific targeting patterns in MOG vs AQP4 antibody-mediated diseases?

OPEN

Both MOGAD and NMOSD target optic nerves and spinal cord preferentially despite different antigen distributions (MOG on myelin vs AQP4 on astrocytes). The mechanism underlying this shared tissue tropism remains unexplained and could inform therapeutic targeting. Gap type: unexplained_observation Source paper: Uncommon Non-MS Demyelinating Disorders of the Central Nervous System. (2025, Current neurology and neuroscience reports, PMID:40591029)

Priority: 0.77 Domain: neuroinflammation Hypotheses: 0
📊 Landscape Analysis

Landscape Summary: What determines the tissue-specific targeting patterns in MOG vs AQP4 antibody-mediated diseases? is a 0.77 priority gap in neuroinflammation. It has 0 linked hypotheses with average composite score 0.000. Status: open.

Key Unanswered Questions

Key Researchers

Colonna, Sevlever, et al. (TREM2 biology)

Clinical Trials

What determines the tissue-specific targeting patterns in MOG vs AQP4 antibody-mediated diseases? — INVOKE-2 (completed)

📈 Living Dashboards
0
Hypotheses
0.000
Top Score
0.000
Avg Score
0
Debates
0.00
Avg Quality
0%
Resolution
0
Mechanistic Families
Gap Resolution Progress0%

Hypothesis Score Distribution

🏆 Competing Hypotheses (Ranked by Score)

No hypotheses linked to this gap yet.

🌊 Knowledge Graph Connections

activates (1)

AQP4→COMPLEMENT CASCADE

associated with (6)

AQP4→Neuromyelitis Optica Spectrum DisorderMOG→MOGADAQP4→Sepsis-Associated EncephalopathyAQP4→NEUROMYELITIS OPTICA SPECTRUM DISORDERAQP4→CSF-ISF Exchange
▸ Show 1 more

binds (5)

calmodulin→AQP4AQP4-ANTIBODY→AQP4AQP4→Aquaporin-4-IgGIGG AUTOANTIBODY→AQP4AQP4-Ab→AQP4

biomarker for (8)

MOG→Myelin Oligodendrocyte Glycoprotein Antibody-Associated DiseaseMOG→Myelin Oligodendrocyte Glycoprotein-Associated DiseaseAQP4→NEUROMYELITIS OPTICA SPECTRUM DISORDERAQP4→Neuromyelitis OpticaMOG→MOGAD
▸ Show 3 more

component of (2)

AQP4→Glymphatic PathwayAQP4→Glymphatic System

data in (2)

ds-f2c28aed24a7→MOGds-f2c28aed24a7→AQP4

detects glymphatic dysfunction (1)

H5_AQP4→AQP4

encodes (1)

AQP4→AQP4

enhances function (1)

H2→AQP4

expressed in (3)

AQP4→Central Nervous SystemAQP4→Astrocytic EndfeetAQP4→Astrocyte Endfeet

inhibits (1)

AQP4→Astrocytic Autophagy

involved in (5)

AQP4→Glymphatic DysfunctionAQP4→CNS edemaAQP4→Glymphatic PathwayAQP4→GLYMPHATIC SYSTEMAQP4→Beta-Amyloid Clearance

mediates (7)

AQP4→Glymphatic ClearanceAQP4→glymphatic pathwayAQP4→Glymphatic TransportAQP4→Perivascular Water TransportAQP4→Water Flux
▸ Show 2 more

provides data for (2)

AQP4→ds-f2c28aed24a7MOG→ds-f2c28aed24a7

regulates (3)

AQP4→Tau ClearanceAQP4→Amyloid Beta ClearanceAQP4→CHI3L1

targets (1)

TGN-020→AQP4

upregulates (1)

Cecal Ligation and Perforation→AQP4
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