Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SEPSIS-ASSOCIATED ENCEPHALOPATHY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | SEPSIS-ASSOCIATED ENCEPHALOPATHY |
Knowledge base pages for this entity
graph TD
SEPSIS_ASSOCIATED_ENCEPHALOPAT["SEPSIS-ASSOCIATED ENCEPHALOPATHY"]
Gut_Brain_Axis["Gut-Brain Axis"] -->|"involved_in"| SEPSIS_ASSOCIATED_ENCEPHALOPAT
Microglial_Responses["Microglial Responses"] -->|"contributes to"| SEPSIS_ASSOCIATED_ENCEPHALOPAT
Peripheral_Immune_Cell_Infiltr["Peripheral Immune Cell Infiltration"] -->|"contributes to"| SEPSIS_ASSOCIATED_ENCEPHALOPAT
Vagus_Nerve["Vagus Nerve"] -->|"mediates"| SEPSIS_ASSOCIATED_ENCEPHALOPAT
Gut_Microbiota_Disruption["Gut Microbiota Disruption"] -->|"risk_factor_for"| SEPSIS_ASSOCIATED_ENCEPHALOPAT
Hypothalamic_Pituitary_Adrenal["Hypothalamic-Pituitary-Adrenal Axis"] -->|"contributes to"| SEPSIS_ASSOCIATED_ENCEPHALOPAT
Serotonin["Serotonin"] -->|"modulates"| SEPSIS_ASSOCIATED_ENCEPHALOPAT| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| AQP4 | associated_with | gene | 0.95 |
| Gut-Brain Axis | involved_in | pathway | 0.95 |
| Qingqi Liangying Formula | protects_against | drug | 0.95 |
| Sepsis | causes | disease | 0.95 |
| Microglial Responses | contributes_to | process | 0.90 |
| Gut-Brain Axis | contributes_to | mechanism | 0.90 |
| Inflammatory Signals | causes | process | 0.90 |
| TNF | associated_with | gene | 0.90 |
| Peripheral Immune Cell Infiltration | contributes_to | process | 0.85 |
| Vagus Nerve | mediates | structure | 0.85 |
| Gut Microbiota Disruption | risk_factor_for | process | 0.85 |
| Vagus Nerve Pathway | modulates | pathway | 0.85 |
| Hpa Axis | modulates | pathway | 0.85 |
| Neuroimmune Pathway | modulates | pathway | 0.85 |
| Microbial Regulation | modulates | pathway | 0.85 |
| Qingqi Liangying formula | treats | drug | 0.85 |
| IL1B | contributes_to | gene | 0.85 |
| pyroptosis | contributes_to | process | 0.85 |
| Hypothalamic-Pituitary-Adrenal Axis | contributes_to | pathway | 0.80 |
| HTR1A | modulates | gene | 0.80 |
| TNF | drives | gene | 0.80 |
| Serotonin | modulates | compound | 0.75 |
| sepsis | causes | disease | 0.70 |
| microglial activation | associated_with | process | 0.70 |
| blood-brain barrier dysfunction | activates | process | 0.70 |
| microglial activation | regulates | process | 0.70 |
| neuroinflammation | activates | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||