LRP1 should remain under review until replicated

graph TD
    LRP1_mediated_tau_uptake_["LRP1-mediated tau uptake disruption"] -->|causes| early_tau_propagation["early tau propagation"]
    LRP1_perturbation["LRP1 perturbation"] -->|modulates| trans_synaptic_tau_spread["trans-synaptic tau spread"]
    LRP1["LRP1"] -->|regulates| tau_propagation["tau propagation"]
    LRP1_1["LRP1"] -->|modulates| tau_uptake["tau uptake"]
    LRP1_2["LRP1"] -->|causes| trans_synaptic_tau_spread_3["trans-synaptic tau spread"]
    LRP1_blockade["LRP1 blockade"] -->|prevents| tau_spreading["tau spreading"]
    LRP1_4["LRP1"] -->|activates| tau_propagation_cascade["tau propagation cascade"]
    LRP1_inhibition["LRP1 inhibition"] -->|prevents| tau_propagation_5["tau propagation"]
    style LRP1_mediated_tau_uptake_ fill:#4fc3f7,stroke:#333,color:#000
    style early_tau_propagation fill:#4fc3f7,stroke:#333,color:#000
    style LRP1_perturbation fill:#4fc3f7,stroke:#333,color:#000
    style trans_synaptic_tau_spread fill:#4fc3f7,stroke:#333,color:#000
    style LRP1 fill:#ce93d8,stroke:#333,color:#000
    style tau_propagation fill:#4fc3f7,stroke:#333,color:#000
    style LRP1_1 fill:#ce93d8,stroke:#333,color:#000
    style tau_uptake fill:#4fc3f7,stroke:#333,color:#000
    style LRP1_2 fill:#ce93d8,stroke:#333,color:#000
    style trans_synaptic_tau_spread_3 fill:#4fc3f7,stroke:#333,color:#000
    style LRP1_blockade fill:#4fc3f7,stroke:#333,color:#000
    style tau_spreading fill:#4fc3f7,stroke:#333,color:#000
    style LRP1_4 fill:#ce93d8,stroke:#333,color:#000
    style tau_propagation_cascade fill:#4fc3f7,stroke:#333,color:#000
    style LRP1_inhibition fill:#4fc3f7,stroke:#333,color:#000
    style tau_propagation_5 fill:#4fc3f7,stroke:#333,color:#000