pathway

lipid metabolism

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about lipid metabolism: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2339Connections

3Hypotheses

2Analyses

32Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	lipid metabolism
Key Genes/Proteins	AMPK, SREBF1, PPARGC1A, LDLR, APP
Related Diseases	neurodegeneration, Alzheimer's disease, neuroinflammation
Related Pathways	unfolded protein response, ferroptosis
Linked Hypotheses	5 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    lipid_metabolism["lipid metabolism"] -->|"crosstalk with"| unfolded_protein_response["unfolded protein response"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    lipid_metabolism["lipid metabolism"] -->|"active in"| astrocytes["astrocytes"]
    style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    lipid_metabolism["lipid metabolism"] -->|"active in"| microglia["microglia"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    lipid_metabolism["lipid metabolism"] -->|"active in"| oligodendrocytes["oligodendrocytes"]
    style oligodendrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    lipid_metabolism["lipid metabolism"] -->|"active in"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    lipid_metabolism["lipid metabolism"] -->|"active in"| neural_stem_cells["neural stem cells"]
    style neural_stem_cells fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    lipid_metabolism["lipid metabolism"] -->|"active in"| macrophages["macrophages"]
    style macrophages fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    AMPK["AMPK"] -->|"regulates"| lipid_metabolism["lipid metabolism"]
    style AMPK fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    SREBF1["SREBF1"] -->|"regulates"| lipid_metabolism["lipid metabolism"]
    style SREBF1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PPARGC1A["PPARGC1A"] -->|"regulates"| lipid_metabolism["lipid metabolism"]
    style PPARGC1A fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    neurodegeneration["neurodegeneration"] -->|"involves"| lipid_metabolism["lipid metabolism"]
    style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Alzheimer_s_disease["Alzheimer's disease"] -->|"involves"| lipid_metabolism["lipid metabolism"]
    style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    style lipid_metabolism fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (321)

Target	Relation	Type	Str
unfolded protein response	crosstalk_with	pathway	0.90
astrocytes	active_in	cell_type	0.90
microglia	active_in	cell_type	0.90
oligodendrocytes	active_in	cell_type	0.90
neurons	active_in	cell_type	0.90
neural stem cells	active_in	cell_type	0.90
macrophages	active_in	cell_type	0.80
metabolic syndrome	involved_in	disease	0.80
cognitive resilience	protects_against	phenotype	0.80
neurodegenerative diseases	associated_with	disease	0.70
ferroptosis	regulates	process	0.70
amyloidogenesis	interacts_with	process	0.70
neuroinflammation	regulates	process	0.70
oxidative stress	regulates	process	0.70
cortex	active_in	brain_region	0.70
blood-brain barrier	active_in	brain_region	0.70
sphingolipid signaling	crosstalk_with	pathway	0.70
white matter	active_in	brain_region	0.60
oxidative stress response	crosstalk_with	pathway	0.60
hippocampus	active_in	brain_region	0.60
striatum	active_in	brain_region	0.60
synaptic plasticity	crosstalk_with	pathway	0.60
pyroptosis	crosstalk_with	pathway	0.60
spinal cord	active_in	brain_region	0.60
T cells	active_in	cell_type	0.60
ER stress	mediates	process	0.60
phagocytosis	mediates	process	0.60
ferroptosis	mediates	process	0.60
temporal lobe	active_in	brain_region	0.60
monocytes	active_in	cell_type	0.60
thalamus	active_in	brain_region	0.60
hypothalamus	active_in	brain_region	0.60

Incoming (2018)

Source	Relation	Type	Str
AMPK	regulates	protein	0.95
SREBF1	regulates	gene	0.95
PPARGC1A	regulates	gene	0.90
neurodegeneration	involves	disease	0.90
Alzheimer's disease	involves	disease	0.90
neuroinflammation	involves	disease	0.90
LDLR	participates_in	gene	0.90
ferroptosis	crosstalk_with	pathway	0.90
APP	participates_in	gene	0.90
APOE	participates_in	gene	0.90
CYP46A1	participates_in	gene	0.90
GLIOBLASTOMA	activates	disease	0.90
spinal muscular atrophy	involves	disease	0.90
PRMT1	regulates	gene	0.90
PPARA	involved_in	gene	0.90
SYK	modulates	gene	0.90
APOE	associated_with	gene	0.90
PI3K/AKT/mTOR	regulates	pathway	0.90
ERK	regulates	protein	0.85
gut-brain axis	regulates	pathway	0.82
TREM2 risk variants	inhibits	gene	0.80
SIRT1	regulates	protein	0.80
diabetes	involves	disease	0.80
Parkinson's disease	involves	disease	0.80
glioblastoma	involves	disease	0.80
GBM	participates_in	gene	0.80
APOE4	participates_in	gene	0.80
aging	involves	disease	0.80
PI3K-AKT-mTOR signaling	crosstalk_with	pathway	0.80
SGMS1	participates_in	gene	0.80
frontotemporal dementia	involves	disease	0.80
HMGCR	participates_in	gene	0.80
ALS	participates_in	gene	0.80
ALS	involves	disease	0.80
SPTLC1	participates_in	gene	0.80
CLU	involved_in	gene	0.80
LRRK2	participates_in	gene	0.80
TREM2	regulates	gene	0.75
DAM microglia	active_in	cell_type	0.75
astrocytes	active_in	cell_type	0.75
ferroptosis	regulates	process	0.70
APOE	regulates	gene	0.70
apolipoprotein E	regulates	protein	0.70
BMAL1	regulates	gene	0.70
circadian rhythm	regulates	process	0.70
HCF1	regulates	protein	0.70
APOE4	regulates	gene	0.70
RNA	participates_in	gene	0.70
NF-kB signaling	crosstalk_with	pathway	0.70
TREM2	participates_in	gene	0.70

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocyte APOE4-Specific Lipid Metabolism Correction	0.479	neurodegeneration	Cell type vulnerability in Alzheimers Di
Sphingolipid Metabolism Reprogramming	0.443	neurodegeneration	4R-tau strain-specific spreading pattern
APOE4-Lipid Metabolism Correction	0.425	neurodegeneration	Neuroinflammation and microglial priming

Mentioning Analyses (2)

Scientific analyses that reference this entity

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 0 hypotheses