VEGF-family genetic control of vascular-neuronal coupling in vulnerable hippocampal regions as proximal driver in VEGF Family GWAS Signals and Cerebrovascular-Neuronal Coupling in AD Hippocampus
🧪 Overview
VEGF-family genetic control of vascular-neuronal coupling in vulnerable hippocampal regions should produce a measurable proximal phenotype before late disease pathology. The decisive test is spatial transcriptomics plus vascular imaging ordered against amyloid and tau burden across hippocampal subfields.
🧬 Mechanism
Curated pathway from expert analysis
flowchart TD
A["VEGF Family GWAS Signals<br/>AD Risk Alleles in VEGFA, FLT1, KDR"]
B["Angiogenesis and Vascular Remodeling<br/>Blood-Brain Barrier Integrity"]
C["Vascular-Neuronal Coupling Disruption<br/>Hippocampal CA1 and Subiculum"]
D["Neurovascular Unit Stress<br/>Pericyte and Astrocyte End-foot Dysfunction"]
E["Tau Propagation Acceleration<br/>Neuronal Vulnerability Increased"]
F["AD Cognitive Decline<br/>Memory Consolidation Failure"]
A --> B
B --> C
C --> D
D --> E
E --> F
style A fill:#0d47a1,stroke:#64b5f6,color:#64b5f6
style F fill:#b71c1c,stroke:#ef9a9a,color:#ef9a9a⚖️ Evidence
No linked papers recorded for this hypothesis yet.
🏥 Translation
🧬 3D Protein Structure — VEGF
No curated PDB or AlphaFold mapping for VEGF yet. Search RCSB →
💉 Clinical Trials
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for VEGF.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
🏆 Tournament
🏆 Arenas / Elo
📊 Market Indicators
💾 Resource Usage
No resource usage or linked notebooks recorded for this hypothesis yet.
▸Metadatasource: v1_phase_c_backfill · origin_type: debate_synthesizer
| source | v1_phase_c_backfill |
| origin_type | debate_synthesizer |
| _schema_version | 1 |