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Arginylation of beta-actin regulates actin cytoskeleton and cell motility.
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ID: paper-16794040
📄 Paper Details
Arginylation of beta-actin regulates actin cytoskeleton and cell motility.
["Karakozova M", "Kozak M", "Wong C", "Bailey A", "Yates J", "Mogilner A", "Zebroski H", "Kashina A"]
Abstract
Posttranslational arginylation is critical for mouse embryogenesis, cardiovascular development, and angiogenesis, but its molecular effects and the identity of proteins arginylated in vivo are unknown. We found that beta-actin was arginylated in vivo to regulate actin filament properties, beta-actin localization, and lamella formation in motile cells. Arginylation of beta-actin apparently represents a critical step in the actin N-terminal processing needed for actin functioning in vivo. Thus, po...
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