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ATM functions at the peroxisome to induce pexophagy in response to ROS.
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ID: paper-26344566
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ATM functions at the peroxisome to induce pexophagy in response to ROS.
["Zhang J", "Tripathi D", "Jing J", "Alexander A", "Kim J", "Powell R", "Dere R", "Tait-Mulder J", "Lee J", "Paull T"]
Abstract
Peroxisomes are highly metabolic, autonomously replicating organelles that generate reactive oxygen species (ROS) as a by-product of fatty acid β-oxidation. Consequently, cells must maintain peroxisome homeostasis, or risk pathologies associated with too few peroxisomes, such as peroxisome biogenesis disorders, or too many peroxisomes, inducing oxidative damage and promoting diseases such as cancer. We report that the PEX5 peroxisome import receptor binds ataxia-telangiectasia mutated (ATM) and ...
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