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An FcRn-targeted mucosal vaccine against SARS-CoV-2 infection and transmission.
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ID: paper-37932271
📄 Paper Details
An FcRn-targeted mucosal vaccine against SARS-CoV-2 infection and transmission.
["Li W", "Wang T", "Rajendrakumar A", "Acharya G", "Miao Z", "Varghese B", "Yu H", "Dhakal B", "LeRoith T", "Karunakaran A"]
Abstract
SARS-CoV-2 is primarily transmitted through droplets and airborne aerosols, and in order to prevent infection and reduce viral spread vaccines should elicit protective immunity in the airways. The neonatal Fc receptor (FcRn) transfers IgG across epithelial barriers and can enhance mucosal delivery of antigens. Here we explore FcRn-mediated respiratory delivery of SARS-CoV-2 spike (S). A monomeric IgG Fc was fused to a stabilized spike; the resulting S-Fc bound to S-specific antibodies and FcRn. ...
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