Excessive compression induces cartilage endplate degeneration via the Piezo1/NAT10/mTOR signaling axis.

OBJECTIVE: Cartilage endplate (CEP) is one of the most important components of the functional unit of the spine, and its performance is closely related to mechanical compression. N4-acetylcytidine (ac4C) modification, a recently identified RNA modification, is implicated in the onset and progression of numerous diseases. This study aimed to investigate the role and mechanism of ac4C modification in the process of CEP degeneration induced by excessive compression. METHOD: We validated the regulat...