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Automated Quality Gates

Comprehensive quality checks across hypotheses, debates, and analyses

Overall Status: CRITICAL

603 total flags across 13 active gates

218
Critical
385
Warnings
0
Passing
Missing Evidence: 47Low Scores (<0.3): 35Weak Debates: 50No KG Edges: 50Low Validation: 50Failed Analyses: 21Missing Synthesis: 50Orphaned Hypotheses: 50Thin Descriptions: 50No Target Gene: 50Duplicate / Near-Duplicate Hypotheses: 50High-Value Hypotheses With Weak Debate Support: 50Stale Market Pricing: 50

Missing Evidence — 47 flagged CRITICAL

Hypotheses with no citations or supporting evidence

Item Score/Detail Date
Test hypothesis 2 0.30 2026-04-27
Test hypothesis 2 0.30 2026-04-27
Test hypothesis 2 0.30 2026-04-27
Test hypothesis 2 0.30 2026-04-27
[Archived Hypothesis] 0.05 2026-04-18
[Archived Hypothesis] 0.05 2026-04-17
[Archived Hypothesis] 0.05 2026-04-17
[Archived Hypothesis] 0.05 2026-04-17
[Archived Hypothesis] 0.05 2026-04-17
[Archived Hypothesis] 0.05 2026-04-17
[Archived Hypothesis] 0.05 2026-04-17
[Archived Hypothesis] 0.05 2026-04-17
[Archived Hypothesis] 0.30 2026-04-16
[Archived Hypothesis] 0.30 2026-04-16
[Archived Hypothesis] 0.30 2026-04-16
[Archived Hypothesis] 0.30 2026-04-16
[Archived Hypothesis] 0.30 2026-04-16
[Archived Hypothesis] 0.30 2026-04-16
[Archived Hypothesis] 0.30 2026-04-16
[Archived Hypothesis] 0.30 2026-04-16
[Archived Hypothesis] 0.30 2026-04-16
[Archived Hypothesis] 0.30 2026-04-16
[Archived Hypothesis] 0.30 2026-04-16
[Archived Hypothesis] 0.30 2026-04-16
[Archived Hypothesis] 0.30 2026-04-16

Showing 25 of 47

Low Scores (<0.3) — 35 flagged WARNING

Hypotheses with composite score below 0.3

Item Score/Detail Date
[Archived Hypothesis] 0.05 2026-04-17
[Archived Hypothesis] 0.05 2026-04-17
[Archived Hypothesis] 0.05 2026-04-17
[Archived Hypothesis] 0.05 2026-04-18
[Archived Hypothesis] 0.05 2026-04-18
[Archived Hypothesis] 0.05 2026-04-17
[Archived Hypothesis] 0.05 2026-04-17
[Archived Hypothesis] 0.05 2026-04-17
[Archived Hypothesis] 0.05 2026-04-17
[Archived Hypothesis] 0.05 2026-04-17
[Archived Hypothesis] 0.05 2026-04-17
Alectinib's Putative C1q Binding Derives from Hydrophobic Aggregation Rather Than Direct P 0.10 2026-04-18
CD300f Immunoglobulin Receptor as Neuroinflammatory Brake 0.10 2026-04-18
P2RX7-PANX1 Channel Blockade for Neuroinflammatory Cascade Interruption 0.10 2026-04-18
TYROBP Causal Network Inhibition for Microglial Repolarization 0.10 2026-04-18
AQP4 Water Channel Normalization as Surrogate Marker and Therapeutic Target 0.10 2026-04-18
NLRP3 Inflammasome Suppression via Selective Caspase-1 Inhibition 0.10 2026-04-18
IL-33/ST2 Axis Augmentation for Synaptic Protection 0.10 2026-04-18
TREM2 Agonism with CX3CR1 Antagonism for Microglial Homeostasis 0.10 2026-04-18
C1q Binding Analysis Across ALK Inhibitor Chemical Series Would Resolve Specificity 0.12 2026-04-18
Alectinib Binds Mitochondrial C1q-like Proteins (C1QDC1) Rather Than Circulating C1q 0.12 2026-04-18
C1q Binding Reflects Broader Kinase Inhibitor Promiscuity Rather Than Specific Complement 0.12 2026-04-18
Human Serum Albumin-Mediated Displacement Creates False-Positive C1q Binding Signals 0.13 2026-04-18
Direct C1q Binding Enables FcγR-Independent Complement Activation on Tumor Cells 0.15 2026-04-18
C1q-Alectinib Complexation Facilitates Brain Penetration via Receptor-Mediated Transcytosi 0.16 2026-04-18

Showing 25 of 35

Weak Debates — 50 flagged WARNING

Debates with missing transcript or quality score <0.3

Item Score/Detail Date
Will single-cell and spatial atlases redefine disease by cell-state rather than organ or g 0.00 / 0r 2026-06-09
Is the subjective psychedelic 'trip' necessary for the therapeutic effect, or will non-hal 0.00 / 0r 2026-06-09
Do animal models fail to predict human neuro/immune outcomes so reliably that we should re 0.00 / 0r 2026-06-09
Can AI systems generate genuinely novel scientific hypotheses, or can they only recombine 0.00 / 0r 2026-06-09
Is aging a single targetable process, and does reversing epigenetic information loss offer 0.00 / 0r 2026-06-09
Is impaired sleep-dependent glymphatic clearance a genuine, treatable cause of dementia — 0.00 / 0r 2026-06-09
Is depression better explained as an inflammatory and circuit-plasticity disorder than as 0.00 / 0r 2026-06-09
Does Parkinson's disease begin in the gut and ascend the vagus nerve (body-first), rather 0.00 / 0r 2026-06-09
Are microglia net-protective early in neurodegeneration and net-destructive late — so the 0.00 / 0r 2026-06-09
Is chronic low-grade inflammation (inflammaging) a root cause of age-related disease, or a 0.00 / 0r 2026-06-09
Is cancer fundamentally an immune-evasion disease that should be treated immunotherapy-fir 0.00 / 0r 2026-06-09
Do clonally-expanded T cells invading the brain drive Parkinson's and Alzheimer's — making 0.00 / 0r 2026-06-09
Does the modest clinical benefit of lecanemab and donanemab confirm the amyloid cascade hy 0.00 / 0r 2026-06-09
single-round debate 0.00 / 0r 2026-05-16
single-round debate 0.00 / 0r 2026-05-16
multi-round debate with scores 0.00 / 0r 2026-05-16
single-round debate 0.00 / 0r 2026-05-16
single-round debate 0.00 / 0r 2026-05-16
multi-round debate with scores 0.00 / 0r 2026-05-16
single-round debate 0.00 / 0r 2026-05-16
single-round debate 0.00 / 0r 2026-05-16
multi-round debate with scores 0.00 / 0r 2026-05-16
single-round debate 0.00 / 0r 2026-05-16
what does the Allen Institute do? 0.00 / 0r 2026-05-04
Structured Research Brief: Tau/MAP6 ratio as a master switch for microtubule dynamics plas 0.72 / 2r 2026-04-28

Showing 25 of 50

No KG Edges — 50 flagged WARNING

Completed analyses that generated no knowledge graph edges

Item Score/Detail Date
Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via 2026-04-28
Gamma entrainment therapy to restore hippocampal-cortical synchrony 2026-04-28
Closed-loop optogenetic targeting PV interneurons to restore theta-gamma coupling and prev 2026-04-28
Can retromer-stabilizing compounds like R55 prevent neurodegeneration in vivo? 2026-04-26
What is the minimum effective dose of trazodone required for disease-modifying effects in 2026-04-26
What is the optimal dosage and timing of melatonin administration for AD prevention and tr 2026-04-26
How does the intron-retained RNA isoform mechanistically reduce glucocerebrosidase protein 2026-04-26
Can CSF p-tau217 normalization serve as a reliable surrogate endpoint for determining dona 2026-04-26
What blood-brain barrier permeability changes serve as early biomarkers for neurodegenerat 2026-04-26
Orexin-A manipulation in AD cognition and circadian dysfunction 2026-04-26
Seed-competent tau conformers in trans-synaptic spread 2026-04-26
Ferroptosis in ALS motor neuron vulnerability 2026-04-26
What blood-brain barrier permeability changes serve as early biomarkers for neurodegenerat 2026-04-26
What blood-brain barrier permeability changes serve as early biomarkers for neurodegenerat 2026-04-26
TREM2 in Alzheimer's Disease: Mechanisms, Therapeutics, and Biomarkers 2026-04-26
Blood-brain barrier permeability changes as early biomarkers for neurodegeneration 2026-04-26
Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration 2026-04-25
What are the optimal oxygen pressure, duration, and frequency parameters for HBOT in AD tr 2026-04-25
What mechanisms drive the self-amplifying vicious cycle linking oxidative stress to cell d 2026-04-25
Does restoring neuronal AMPK activity reverse microglial inflammation in vivo? 2026-04-25
Can ferroptosis inhibitors prevent BBB disruption and edema formation after cardiac arrest 2026-04-25
Which specific factors in conditioned medium from healthy astrocytes rescue motor neuron d 2026-04-25
Does the cancer-cystatin-C-TREM2 pathway protect against tau pathology and other AD hallma 2026-04-25
How does lncRNA-0021 achieve sequence-specific binding to mmu-miR-6361 and what determines 2026-04-25
Which specific CSF molecular components are essential for maintaining disease-relevant α-s 2026-04-25

Showing 25 of 50

Low Validation — 50 flagged WARNING

Hypotheses with evidence validation score below 0.4

Item Score/Detail Date
[Archived Hypothesis] 0.30
[Archived Hypothesis] 0.30
[Archived Hypothesis] 0.30
[Archived Hypothesis] 0.30
[Archived Hypothesis] 0.30
[Archived Hypothesis] 0.30
[Archived Hypothesis] 0.30
[Archived Hypothesis] 0.30
[Archived Hypothesis] 0.30
[Archived Hypothesis] 0.30
[Archived Hypothesis] 0.30
[Archived Hypothesis] 0.30
[Archived Hypothesis] 0.30
[Archived Hypothesis] 0.30
Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-gamma coup 0.86
Gamma Oscillation Enhancement Synergy 0.84
[Archived Hypothesis] 0.30
[Archived Hypothesis] 0.30
[Archived Hypothesis] 0.30
[Archived Hypothesis] 0.30
[Archived Hypothesis] 0.30
[Archived Hypothesis] 0.30
[Archived Hypothesis] 0.30
AMPK hypersensitivity in astrocytes creates enhanced mitochondrial rescue responses 0.83
Optogenetic restoration of hippocampal gamma oscillations via selective PV interneuron act 0.87

Showing 25 of 50

Failed Analyses — 21 flagged CRITICAL

Analyses that failed to complete

Item Score/Detail Date
Test Orchestrator error: 'theorist' 2026-05-11
Test Orchestrator error: 'theorist' 2026-05-10
Test Orchestrator error: 'theorist' 2026-05-06
Test Orchestrator error: 'theorist' 2026-05-05
Test Orchestrator error: 'theorist' 2026-05-04
Test Orchestrator error: 'theorist' 2026-05-03
Test Orchestrator error: 'theorist' 2026-05-02
Test Orchestrator error: 'theorist' 2026-05-01
Test Orchestrator error: 'theorist' 2026-04-30
Test Orchestrator error: 'theorist' 2026-04-29
Test Orchestrator error: 'theorist' 2026-04-28
Cross-disease neurodegeneration mechanism synthesis 2026-04-28
GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance 2026-04-28
Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hi 2026-04-28
Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evaluate design, Orchestrator error: 'theorist' 2026-04-28
Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia — Rich An Orchestrator error: 'methodologist' 2026-04-28
DPP6 GWAS Signal: Cell-Type Regulatory Networks for PD Cognitive Decline Uncaught in run_debate: BadRequestError: Error cod 2026-04-27
m6A RNA Modification and Alpha-Synuclein Aggregation in Substantia Nigra Uncaught in run_debate: NameError: name 'skeptic_q 2026-04-27
Microglial Priming as Upstream Causal Node Across AD, PD, ALS, MS: Three-Arm Causal Infere 2026-04-27
Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia — Rich An Orchestrator error: 'methodologist' 2026-04-27
Methodology challenge: notebook 'Astrocyte reactivity subtypes in neurodegeneration — Rich Orchestrator error: 'methodologist' 2026-04-27

Missing Synthesis — 50 flagged CRITICAL

Debates with rounds but no synthesizer step

Item Score/Detail Date
Will single-cell and spatial atlases redefine disease by cell-state rather than organ or g 0.00 / 0r 2026-06-09
Is the subjective psychedelic 'trip' necessary for the therapeutic effect, or will non-hal 0.00 / 0r 2026-06-09
Do animal models fail to predict human neuro/immune outcomes so reliably that we should re 0.00 / 0r 2026-06-09
Can AI systems generate genuinely novel scientific hypotheses, or can they only recombine 0.00 / 0r 2026-06-09
Is aging a single targetable process, and does reversing epigenetic information loss offer 0.00 / 0r 2026-06-09
Is impaired sleep-dependent glymphatic clearance a genuine, treatable cause of dementia — 0.00 / 0r 2026-06-09
Is depression better explained as an inflammatory and circuit-plasticity disorder than as 0.00 / 0r 2026-06-09
Does Parkinson's disease begin in the gut and ascend the vagus nerve (body-first), rather 0.00 / 0r 2026-06-09
Are microglia net-protective early in neurodegeneration and net-destructive late — so the 0.00 / 0r 2026-06-09
Is chronic low-grade inflammation (inflammaging) a root cause of age-related disease, or a 0.00 / 0r 2026-06-09
Is cancer fundamentally an immune-evasion disease that should be treated immunotherapy-fir 0.00 / 0r 2026-06-09
Do clonally-expanded T cells invading the brain drive Parkinson's and Alzheimer's — making 0.00 / 0r 2026-06-09
Does the modest clinical benefit of lecanemab and donanemab confirm the amyloid cascade hy 0.00 / 0r 2026-06-09
single-round debate 0.00 / 0r 2026-05-16
single-round debate 0.00 / 0r 2026-05-16
multi-round debate with scores 0.00 / 0r 2026-05-16
single-round debate 0.00 / 0r 2026-05-16
single-round debate 0.00 / 0r 2026-05-16
multi-round debate with scores 0.00 / 0r 2026-05-16
single-round debate 0.00 / 0r 2026-05-16
single-round debate 0.00 / 0r 2026-05-16
multi-round debate with scores 0.00 / 0r 2026-05-16
single-round debate 0.00 / 0r 2026-05-16
Test 0.74 / 4r 2026-05-10
Test 0.77 / 4r 2026-05-06

Showing 25 of 50

Orphaned Hypotheses — 50 flagged WARNING

Hypotheses not linked to any analysis

Item Score/Detail Date
Critical Evaluation of the Allen Brain SEA-AD MTG snRNA-seq Dataset 0.00 2026-04-28
Methodological Evaluation of the SEA-AD MTG Differential Expression Dataset 0.00 2026-04-28
Methodological Vulnerabilities in the SEA-AD snRNA-seq Dataset 0.00 2026-04-28
Critical Evaluation of the Allen Brain SEA-AD Dataset Methodology 0.00 2026-04-28
Synthesis and Constructive Resolution Toward Methodological Reformation in Intercellular M 0.00 2026-04-28
Statistical Underpowering and the Reproducibility Crisis in Mitochondrial Transfer Studies 0.00 2026-04-28
Resolving Mechanistic Heterogeneity Through Precision Medicine and Staged Intervention 0.00 2026-04-28
Advancing Beyond Traditional Druggability Through RNA-Guided Precision Therapeutics 0.00 2026-04-28
Addressing Falsification Through Integrated Multi-Target Framework 0.00 2026-04-28
Advancing Beyond Traditional Druggability Through RNA-Guided Precision Therapeutics 0.00 2026-04-28
Targeting TDP-43 Phase Separation Through Selective RNA-Binding Modulation 0.00 2026-04-28
Concrete Development Roadmap and Final Position 0.00 2026-04-28
Strategic Reframing and Targeted Innovation 0.00 2026-04-28
Convergent Multi-Modal CRISPR Architectures (Continued) 0.00 2026-04-28
Next-Generation CRISPR Innovations for Huntington's Disease 0.00 2026-04-28
Novel CRISPR-based Therapies for Huntington's Disease: A Multi-Target Precision Approach 0.00 2026-04-28
Addressing Unfalsifiability with Precision 0.00 2026-04-28
Defending and Extending the Adaptive Decline Model 0.00 2026-04-28
Astrocyte-Neuron Metabolic Coupling as the Master Plasticity Gatekeeper 0.00 2026-04-28
Astrocyte-Neuron Metabolic Coupling as the Master Plasticity Gatekeeper 0.00 2026-04-28
Gamma entrainment therapy to restore motor cortical inhibitory-excitatory balance in ALS 0.63 2026-04-28
Closed-loop optogenetic targeting of PV interneurons to restore motor circuit inhibition a 0.63 2026-04-28
Closed-loop transcranial focused ultrasound targeting motor cortex SST interneurons to res 0.63 2026-04-28
FUS Phase Separation Dominance in FTD-TDP: Aberrant Condensate Hijacking of RNA Processing 0.68 2026-04-28
Microglial TBK1 Deficiency Triggers Senescence-Associated Secretory Phenotype in Frontotem 0.65 2026-04-28

Showing 25 of 50

Thin Descriptions — 50 flagged WARNING

Hypotheses with description under 100 characters

Item Score/Detail Date
Test hypothesis 0 0.70 2026-04-27
Test hypothesis 0 0.70 2026-04-27
Test hypothesis 0 0.70 2026-04-27
Test hypothesis 0 0.70 2026-04-27
E2E direct hypothesis a980051375 0.66 2026-04-26
Manual uptake test 0.60 2026-04-27
Manual uptake test 0.60 2026-04-27
H3K9me3 Heterochromatin Loss at Pericentromeric Repeats 0.56 2026-04-25
Circulating hs-CRP as Disease-Modifying Target via Microglial IL-1β Amplification 0.56 2026-04-25
BET Bromodomain Inhibition for Neuroinflammation Suppression 0.55 2026-04-25
NAD+ Precursor Supplementation to Reverse Poly(ADP-ribose) Polymerase-Driven Metabolic Cat 0.55 2026-04-25
Microglial TREM2 Activation to Enhance Synaptic Pruning Regulation 0.53 2026-04-25
PLIN2 (Perilipin-2) Degradation via Autophagy Activation to Clear Disease-Associated Lipid 0.53 2026-04-25
Polycomb-to-Trithorax Switch at Synaptic Plasticity Genes 0.53 2026-04-25
VPS35 Retromer Restoration to Rescue Endosomal Protein Trafficking 0.52 2026-04-25
Astrocyte-Specific DGAT1 Inhibition to Prevent Lipid Droplet-Induced Neuroinflammation 0.51 2026-04-25
Anti-CD47/SIRPα Checkpoint Therapy to Enhance Phagocytic Clearance 0.51 2026-04-25
CCR2+ Monocyte Depletion as Restoration of CNS Immune Privilege 0.50 2026-04-25
Glymphatic-Mediated Tau Clearance Dysfunction (Proteomics DE) 0.50 2026-04-26
Test hypothesis 1 0.50 2026-04-27
Test hypothesis 1 0.50 2026-04-27
APOE4-Specific Lipidation Enhancement Therapy (Cell-Cell Communication) 0.50 2026-04-26
Test hypothesis 1 0.50 2026-04-27
Test hypothesis 1 0.50 2026-04-27
USP14 Inhibition to Accelerate Proteasomal Degradation of Synaptic Substrates 0.49 2026-04-25

Showing 25 of 50

No Target Gene — 50 flagged WARNING

Hypotheses without an assigned target gene

Item Score/Detail Date
Complement Cascade Inhibition Synaptic Protection 0.87 2026-04-17
Gamma Oscillation Enhancement Synergy 0.84 2026-04-17
Dual-Receptor Antibody Shuttling 0.80 2026-04-13
Lysosomal Cathepsin-Dependent Tau Clearance 0.77 2026-04-17
Test hypothesis 0 0.70 2026-04-27
Test hypothesis 0 0.70 2026-04-27
Test hypothesis 0 0.70 2026-04-27
Test hypothesis 0 0.70 2026-04-27
EPO Set Point Calibration Hypothesis 0.65 2026-04-13
Dual Calpain/Cathepsin B Inhibition as Primary Neuroprotective Strategy 0.64 2026-04-15
Closed-loop optogenetic targeting of PV interneurons to restore motor circuit inhibition a 0.63 2026-04-28
Cell-state stratification is required to resolve Sex-Specific Microglial States in Amyloid 0.61 2026-04-28
Cell-state stratification is required to resolve Proteogenomic Network Hubs as Druggable T 0.61 2026-04-28
Cell-state stratification is required to resolve Genetic Aging Landscape Variants and Epig 0.61 2026-04-28
Perturbation-first validation should precede therapeutic claims for Causal Sequence of TDP 0.61 2026-04-28
Perturbation-first validation should precede therapeutic claims for Proteogenomic Network 0.61 2026-04-28
Perturbation-first validation should precede therapeutic claims for Non-Neuronal Transcrip 0.61 2026-04-28
Perturbation-first validation should precede therapeutic claims for Sex-Specific Microglia 0.61 2026-04-28
Perturbation-first validation should precede therapeutic claims for Genetic Aging Landscap 0.61 2026-04-28
Perturbation-first validation should precede therapeutic claims for DPP6 GWAS Signal: Cell 0.61 2026-04-28
Manual uptake test 0.60 2026-04-27
Manual uptake test 0.60 2026-04-27
Gamma Entrainment Synergy: HBOT-Enhanced Cerebral Perfusion Amplifies SST Interneuron-Targ 0.58 2026-04-17
Oxygen Pressure-Dependent BDNF Cascade: DHHC2/PSD95 Stabilization for Synaptic Rescue 0.58 2026-04-17
Hepcidin-Iron Set Point Hypothesis 0.58 2026-04-13

Showing 25 of 50

Duplicate / Near-Duplicate Hypotheses — 50 flagged CRITICAL

Pairs of hypotheses with >=60% title overlap; merge, consolidate, or down-rank the weaker duplicate

Item Score/Detail Date
Plasma NfL Elevation Secondary to BBB-Asso vs Plasma NfL Elevation Secondary to BBB-Asso 100% / shared gene candidate
TREM2-Mediated Astrocyte-Microglia Crossta vs TREM2-Mediated Astrocyte-Microglia Cross-T 100% / shared gene candidate
TREM2-Mediated Astrocyte-Microglia Crossta vs TREM2-Mediated Astrocyte-Microglia Cross-T 100% / shared gene candidate
TREM2-Mediated Astrocyte-Microglia Crossta vs TREM2-Mediated Astrocyte-Microglia Cross-T 100% / shared gene candidate
Extracellular Vesicle Biogenesis Modulatio vs Extracellular Vesicle Biogenesis Modulatio 100% / shared gene candidate
LRP1-Dependent Tau Uptake Disruption vs LRP1-Dependent Tau Uptake Disruption 100% / shared gene candidate
VCP-Mediated Autophagy Enhancement vs VCP-Mediated Autophagy Enhancement 100% / shared gene candidate
TREM2-mediated microglial tau clearance en vs TREM2-mediated microglial tau clearance en 100% / shared gene candidate
Test: TREM2 enhances amyloid clearance vs Test: TREM2 enhances amyloid clearance 100% / shared gene candidate
Test: TREM2 enhances amyloid clearance vs Test: TREM2 enhances amyloid clearance 100% / shared gene candidate
Test: TREM2 enhances amyloid clearance vs Test: TREM2 enhances amyloid clearance 100% / shared gene candidate
Test: TREM2 enhances amyloid clearance vs Test: TREM2 enhances amyloid clearance 100% / shared gene candidate
Test: TREM2 enhances amyloid clearance vs Test: TREM2 enhances amyloid clearance 100% / shared gene candidate
Test: TREM2 enhances amyloid clearance vs Test: TREM2 enhances amyloid clearance 100% / shared gene candidate
Test: TREM2 enhances amyloid clearance vs Test: TREM2 enhances amyloid clearance 100% / shared gene candidate
Test: TREM2 enhances amyloid clearance vs Test: TREM2 enhances amyloid clearance 100% / shared gene candidate
Test: TREM2 enhances amyloid clearance vs Test: TREM2 enhances amyloid clearance 100% / shared gene candidate
Test: TREM2 enhances amyloid clearance vs Test: TREM2 enhances amyloid clearance 100% / shared gene candidate
Test: TREM2 enhances amyloid clearance vs Test: TREM2 enhances amyloid clearance 100% / shared gene candidate
Test: TREM2 enhances amyloid clearance vs Test: TREM2 enhances amyloid clearance 100% / shared gene candidate
Test: TREM2 enhances amyloid clearance vs Test: TREM2 enhances amyloid clearance 100% / shared gene candidate
Test: TREM2 enhances amyloid clearance vs Test: TREM2 enhances amyloid clearance 100% / shared gene candidate
Test: TREM2 enhances amyloid clearance vs Test: TREM2 enhances amyloid clearance 100% / shared gene candidate
Circulating Soluble PDGFRβ Reflects Pericy vs Circulating Soluble PDGFRβ Reflects Pericy 100% / shared gene candidate
Matrix Metalloproteinase-9 and TIMP-1 Rati vs Matrix Metalloproteinase-9 and TIMP-1 Rati 100% / shared gene candidate

Showing 25 of 50

High-Value Hypotheses With Weak Debate Support — 50 flagged CRITICAL

Scientifically promising hypotheses whose analyses still have no strong debate record

Item Score/Detail Date
eIF2α Phosphorylation Imbalance Creates Integrated Stress Response Overflow That Represses 0.00 / 0 debates never
RBM45 Liquid-Liquid Phase Separation Dominance Hijacks RNA Processing Condensates Toward P 0.00 / 0 debates never
SFPQ Paralog Displacement Triggers Cryptic Polyadenylation and Global RNA Stability Loss i 0.00 / 0 debates never
hnRNP A2/B1 Staufen2-Mediated Axonal RNA Granule Transport Failure Drives Distal Axon Dege 0.00 / 0 debates never
ATM Kinase Hyperactivation Triggers DNA Damage Response Overflow and p53-Dependent Motor N 0.00 / 0 debates never
GLE1-Mediated mRNA Export Defect Creates Translation-Competent mRNA Starvation in ALS Moto 0.00 / 0 debates never
TIA1 Low-Complexity Domain Oxidation Drives Aberrant Stress Granule Assembly and TDP-43 Mi 0.00 / 0 debates never
Dual-Receptor Antibody Shuttling 0.00 / 0 debates never
MATR3 Nuclear Body Disruption Impairs RNA Processing Hubs and Triggers Splicing Defects in 0.00 / 0 debates never
LAMP2A Liquid-Liquid Phase Separation Defects in Dopaminergic Neurons Create Selective Vul 0.00 / 0 debates never
PINK1/Parkin–TREM2 Axis: Convergent Mitophagy Failure Unifies PD (SNCA/αSyn) and AD (tau/A 0.00 / 0 debates never
APOE4-Specific Proteolytic Fragment Inhibition Therapy 0.00 / 0 debates never
Exosomal SNCA Propagation from Lysosome-Compromised Neurons Contains a Distinct Lysosomal 0.00 / 0 debates never
Synaptic Vesicle Cycle Hijacking: Shared Convergent Mechanism for α-Synuclein (PD) and Tau 0.00 / 0 debates never
GBA1 Loss Triggers a TFEB-to-TFE3 Compensatory Switch in A9 Dopaminergic Neurons that is D 0.00 / 0 debates never
Tau/MAP6 ratio as a master switch for microtubule dynamics plasticity 0.00 / 0 debates never
Tau dysfunction destabilizes labile pool 0.00 / 0 debates never
Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate 0.00 / 0 debates never
GBA1-Deficiency Disrupts Mitochondrial- Lysosomal Contact Sites by Reducing Miro1 Degradat 0.00 / 0 debates never
PD-Associated GWAS Variants in CTSO and CTSF Genes Create a Synthetic Lethal Interaction w 0.00 / 0 debates never
SNCA Oligomer Binding to LAMP2A Cytosolic Tail Prevents TorsinA-Mediated LAMP2A Turnover, 0.00 / 0 debates never
TREM2-APOE4 Axis Drives Metabolic Inflexibility in DAM 0.00 / 0 debates never
NRF2-Mediated Proteostatic Convergence: Shared Oxidative Stress Response Failure Links PD 0.00 / 0 debates never
Lysosomal Acidification Failure: Convergent GBA1/LAMP2A–mediated Autophagy Dysfunction Lin 0.00 / 0 debates never
VPS35 Retromer Dysfunction Creates a GCase Trafficking Bottleneck that Synergizes with GBA 0.00 / 0 debates never

Showing 25 of 50

Stale Market Pricing — 50 flagged WARNING

Hypotheses whose latest debate evidence is newer than their latest price update

Item Score/Detail Date
Perineuronal Net Depolymerization as Early Synaptic Vulnerability Trigger 0 price events 2026-05-03 / never
Glial Metabolic Coupling Failure in Neuronal Bioenergetic Crisis 0 price events 2026-05-03 / never
ACSL4-Mediated Neuroinflammatory Amplification in Disease-Associated Microglia 0 price events 2026-04-28 / never
CYP46A1 Small Molecule Activator Therapy 0 price events 2026-04-27 / never
CYP46A1-Mediated Cholesterol Reduction Prevents eIF2α-Driven Translation Stalling in Neuro 0 price events 2026-04-27 / never
Focused Ultrasound-Enhanced CYP46A1 Gene Therapy for Neurodegeneration 0 price events 2026-04-27 / never
CYP46A1 Inhibition Therapy for Neurodegeneration 0 price events 2026-04-27 / never
TREM2-Mediated Microglial Dysfunction Impairs Synaptic Tau Propagation Blockade 0 price events 2026-04-27 / never
TREM2-Mediated Oligodendrocyte Metabolic Support in White Matter Neurodegeneration 0 price events 2026-04-27 / never
TREM2-Regulated Astrocytic Calcium Dynamics Control Glymphatic Tau Clearance 0 price events 2026-04-27 / never
Closed-loop tFUS targeting of EC-II SST interneurons to prevent ACSL4-mediated ferroptotic 0 price events 2026-04-27 / never
Optogenetic restoration of SST interneuron-mediated dendritic inhibition to rescue hippoca 0 price events 2026-04-27 / never
Dopaminergic Ventral Tegmental-Striatal Circuit Protection 0 price events 2026-04-27 / never
GluN2B-Mediated Microglial Activation and Tau Phagocytosis 0 price events 2026-04-27 / never
Real-time optogenetic activation of CA3 PV interneurons to restore theta-gamma coupling an 0 price events 2026-04-27 / never
Enhancing Heparan Sulfate 3-O-Sulfotransferase Activity to Competitively Block Tau-HSPG In 0 price events 2026-04-27 / never
SULF-Mediated Protection of Cholinergic Tau Transport Pathways 0 price events 2026-04-27 / never
Enteric Nervous System Prion-Like Propagation Blockade 214 price events 2026-04-27 / 2026-04-27
Theta-Gamma Cross-Frequency Coupling Modulates lncRNA-9969 Phase-Dependent Translation in 0 price events 2026-04-25 / never
Theta-Alpha Oscillation Entrainment Enhances lncRNA-9969-Mediated Mitochondrial Biogenesis 0 price events 2026-04-25 / never
Transcranial Magnetic Stimulation-Induced Nanoparticle Delivery via Neuronal Activity Modu 0 price events 2026-04-22 / never
Lentiviral-Mediated Astrocytic IGFBPL1 Expression via GFAP Promoter 0 price events 2026-04-22 / never
FUS-Enhanced AAV-PHP.eB Delivery for Microglial IGFBPL1 Expression 0 price events 2026-04-22 / never
Ultrasound-Responsive Liposomal Nanocarriers with Thermosensitive Release 0 price events 2026-04-22 / never
AAV-PHP.eB-Mediated Astrocytic IGFBPL1 Expression 0 price events 2026-04-22 / never

Showing 25 of 50

Artifact Quality Gates — All Types

3984 artifact(s) evaluated · JSON summary →

Type Gate Pass Fail Pass Rate
ai_image metadata 1 0
100%
ai_image title 1 0
100%
analysis metadata 8 0
100%
analysis title 8 0
100%
analysis_proposal metadata 58 0
100%
analysis_proposal title 58 0
100%
code_proposal metadata 10 0
100%
code_proposal title 10 0
100%
dashboard metadata 30 0
100%
dashboard title 30 0
100%
dataset metadata 121 0
100%
dataset provenance 1 120
1%
dataset schema 1 120
1%
dataset size 121 0
100%
dataset title 121 0
100%
experiment_proposal metadata 29 0
100%
experiment_proposal title 29 0
100%
experiment_result metadata 1 0
100%
experiment_result title 1 0
100%
external_proposal metadata 1 0
100%
external_proposal title 1 0
100%
figure metadata 16 0
100%
figure quality_score 16 0
100%
figure title 16 0
100%
funding_proposal metadata 12 0
100%
funding_proposal title 12 0
100%
hypothesis metadata 1112 0
100%
hypothesis title 1112 0
100%
model data_provenance 1 0
100%
model metadata 2 0
100%
model specification 1 0
100%
model title 2 0
100%
model validation 2 0
100%
notebook content 47 8
85%
notebook description 47 8
85%
notebook metadata 55 0
100%
notebook quality_score 31 0
100%
notebook title 55 0
100%
open_question metadata 1790 0
100%
open_question title 1790 0
100%
paper quality_score 60 0
100%
paper_figure metadata 406 0
100%
paper_figure title 404 2
100%
portfolio_artifact metadata 1 0
100%
portfolio_artifact title 1 0
100%
research_plan metadata 14 0
100%
research_plan title 14 0
100%
sc_trajectory metadata 3 0
100%
sc_trajectory title 3 0
100%
upstream_target metadata 58 0
100%
upstream_target title 58 0
100%
wiki_page metadata 195 0
100%
wiki_page title 178 17
91%

Quality Trend History

Time Total No Evid. Low Score Weak Deb. No KG Low Val. Failed No Synth. Orphaned
2026-04-16 04:04 526 51 0 24 51 14 200 1 62
2026-04-16 05:05 757 51 0 27 51 14 200 1 62
2026-04-16 06:13 544 53 0 31 52 14 201 1 64
2026-04-16 07:24 551 54 0 31 52 14 202 1 66
2026-04-16 08:33 559 56 0 31 52 14 202 1 68
2026-04-16 09:38 567 58 0 31 52 14 202 1 70
2026-04-16 10:44 1385 61 0 32 52 14 202 1 73
2026-04-16 12:47 643 77 0 45 52 14 202 1 82
2026-04-16 13:54 647 86 1 18 52 14 202 1 89
2026-04-16 15:24 676 91 1 26 53 14 202 1 94
2026-04-16 16:24 773 95 1 26 54 94 202 1 98
2026-04-16 17:30 778 103 1 26 52 94 202 1 99
2026-04-16 18:49 764 95 1 26 48 94 202 1 99
2026-04-16 20:09 760 96 1 15 48 94 203 1 102
2026-04-16 21:17 1524 96 1 15 51 94 199 1 102
2026-04-16 22:30 747 96 1 14 39 94 200 1 102
2026-04-17 03:42 1622 91 1 32 53 94 202 1 103
2026-04-17 08:11 614 101 0 20 54 96 1 1 111
2026-04-17 09:17 630 105 0 20 54 96 1 1 115
2026-04-17 10:24 634 106 0 20 54 96 1 1 116
2026-04-17 11:28 629 101 0 20 54 96 1 1 116
2026-04-17 13:09 642 104 0 20 54 96 2 1 119
2026-04-17 14:12 1471 105 0 20 54 96 2 1 120
2026-04-17 19:45 1593 105 0 20 54 96 2 1 120
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