| Gene Symbol | ADAMTS4 |
| Aliases | ADAMTS4PROTEIN |
| Protein Type | Protease |
| Function | ADAMTS4 encodes a member of the ADAMTS (A Disintegrin And Metalloproteinase with Thrombospondin motifs) family of secreted zinc metalloproteinases. |
| Subcellular Localization | Secreted enzyme; localized to the extracellular space and cell surface |
| Exons | 8 |
| Pathways | Circadian Rhythm, Tgf-Β, TGF-beta signaling |
| Ensembl ID | ENSG00000158859 |
| GeneCards | ADAMTS4 |
| Human Protein Atlas | ADAMTS4 |
| Transcriptional | NF-κB, AP-1, and RUNX2 control gene expression in response to inflammatory signals |
| Endogenous inhibitors | TIMP-3 is the primary physiological inhibitor; binds the catalytic domain with nanomolar affinity |
| Substrate availability | ECM composition and CSPG accessibility determine activity |
| C-terminal processing | Removal of the spacer domain by MT4-MMP generates a more active truncated enzyme with broader substrate specificity |
| Associated Diseases | Alzheimer's Disease (AD |
| Interactions | ADAM10, AGING, BIN1, BMAL1, FBN1, Metalloproteinase |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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