protein

Metalloproteinase

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Metalloproteinase: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

152Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	Metalloproteinase
Associated Diseases	Aging, Als, Alzheimer, Senescence
Interactions	STROKE, MMP9, AEP, TRKB, AGING, MMP2
KG Connections	152 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Metalloproteinase["Metalloproteinase"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
    style Fibrosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Metalloproteinase["Metalloproteinase"] -->|"therapeutic target"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Metalloproteinase["Metalloproteinase"] -->|"activates"| Aging["Aging"]
    style Aging fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Metalloproteinase["Metalloproteinase"] -->|"activates"| Ischemia["Ischemia"]
    style Ischemia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Metalloproteinase["Metalloproteinase"] -->|"activates"| Stroke["Stroke"]
    style Stroke fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Metalloproteinase["Metalloproteinase"] -->|"biomarker for"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Metalloproteinase["Metalloproteinase"] -->|"contributes to"| Dementia["Dementia"]
    style Dementia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    IGF1R["IGF1R"] -->|"therapeutic target"| Metalloproteinase["Metalloproteinase"]
    style IGF1R fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    DAG1["DAG1"] -->|"therapeutic target"| Metalloproteinase["Metalloproteinase"]
    style DAG1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    RNA["RNA"] -->|"therapeutic target"| Metalloproteinase["Metalloproteinase"]
    style RNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ROS["ROS"] -->|"associated"| Metalloproteinase["Metalloproteinase"]
    style ROS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    HSPG2["HSPG2"] -->|"therapeutic target"| Metalloproteinase["Metalloproteinase"]
    style HSPG2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Metalloproteinase fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (55)

Target	Relation	Type	Str
Fibrosis	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Aging	activates	disease	0.60
Ischemia	activates	disease	0.60
Stroke	activates	disease	0.60
Aging	biomarker_for	disease	0.60
Cancer	biomarker_for	disease	0.60
Als	biomarker_for	disease	0.60
Dementia	contributes_to	disease	0.60
Alzheimer	contributes_to	disease	0.60
Aging	contributes_to	disease	0.60
Als	contributes_to	disease	0.60
Huntington	contributes_to	disease	0.60
Ferroptosis	activates	disease	0.60
Als	activates	disease	0.60
Fibrosis	activates	disease	0.60
Alzheimer	biomarker_for	disease	0.60
Lymphoma	activates	disease	0.60
Cancer	inhibits	disease	0.60
Hypertension	activates	disease	0.60
Aging	causes	disease	0.60
Neuroinflammation	activates	disease	0.60
Alzheimer	causes	disease	0.60
Als	causes	disease	0.60
Atherosclerosis	activates	disease	0.60
Senescence	associated_with	disease	0.60
Parkinson	activates	disease	0.60
Alzheimer	activates	disease	0.60
Schizophrenia	expressed_in	disease	0.60
Alzheimer	expressed_in	disease	0.60
Cancer	expressed_in	disease	0.60
Atherosclerosis	expressed_in	disease	0.60
Als	expressed_in	disease	0.60
Aging	expressed_in	disease	0.60
Blood-Brain Barrier	expressed_in	pathway	0.55
Blood-Brain Barrier	contributes_to	pathway	0.55
Circadian Rhythm	activates	pathway	0.55
Autophagy	activates	pathway	0.55
Mtor	activates	pathway	0.55
Nf-Κb	associated_with	pathway	0.55
Immune Response	associated_with	pathway	0.55
Toll-Like Receptor	regulates	pathway	0.55
Apoptosis	inhibits	pathway	0.55
Oxidative Stress	activates	pathway	0.55
Mapk	activates	pathway	0.55
Immune Response	activates	pathway	0.55
Apoptosis	activates	pathway	0.55
Nf-Κb	activates	pathway	0.55
Innate Immunity	activates	pathway	0.55
Inflammasome	activates	pathway	0.55

Incoming (97)

Source	Relation	Type	Str
IGF1R	therapeutic_target	gene	0.60
DAG1	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
ROS	associated_with	gene	0.60
HSPG2	therapeutic_target	gene	0.60
STROKE	activates	gene	0.60
MMP9	activates	gene	0.60
AEP	activates	gene	0.60
TRKB	activates	gene	0.60
AGING	activates	gene	0.60
MMP2	activates	gene	0.60
MMP9	inhibits	gene	0.60
CD68	biomarker_for	gene	0.60
CD14	biomarker_for	gene	0.60
CYTOKINES	biomarker_for	gene	0.60
AGING	biomarker_for	gene	0.60
MMP2	inhibits	gene	0.60
CD163	biomarker_for	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
ALZHEIMER	contributes_to	gene	0.60
DEMENTIA	contributes_to	gene	0.60
PERICYTE	activates	gene	0.60
TAU	activates	gene	0.60
HUNTINGTON	contributes_to	gene	0.60
APOE4	activates	gene	0.60
ADAMTS4	activates	gene	0.60
BMAL1	activates	gene	0.60
MMP1	activates	gene	0.60
GPX4	activates	gene	0.60
P53	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
SLC7A11	activates	gene	0.60
SOX9	activates	gene	0.60
ROS	activates	gene	0.60
MMP3	activates	gene	0.60
IL-1	activates	gene	0.60
ANXA2	activates	gene	0.60
ADAM8	regulates	gene	0.60
MTOR	activates	gene	0.60
RNA	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
P62	activates	gene	0.60
EXOSOMES	biomarker_for	gene	0.60
C1QC	inhibits	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
TAU	biomarker_for	gene	0.60
AMYLOID	biomarker_for	gene	0.60
C1Q	inhibits	gene	0.60
COMPLEMENT	inhibits	gene	0.60
RAS	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Metalloproteinase

Understanding Entity Pages

Wiki Pages (20)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Blood-Brain Barrier Dysfunction in Neurodegeneration

amyloid-beta-metalloproteinases

gabaergic-dysfunction

Vitamin D Signaling Pathway in Neurodegeneration

Blood-Brain Barrier Biology and Crossing Strategies

blood-brain-barrier

Amyloid Cascade Pathway

Astrocytes

neurovascular-coupling

Multiple Sclerosis (MS)

Genistein for Mild Cognitive Impairment (NCT07385937)

Notch Signaling Pathway in Neurodegeneration

NF-kB Signaling Pathway in Neurodegeneration

Cellular Senescence in Neurodegeneration

NF-κB Signaling Pathway in Neurodegeneration

Neuroinflammation Across AD, PD, ALS, FTD, and HD

neurovascular-dysfunction