concept

METALLOPROTEINASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about METALLOPROTEINASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

152Connections

4Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	METALLOPROTEINASE

Pathway Diagram

graph TD
    METALLOPROTEINASE["METALLOPROTEINASE"]
    style METALLOPROTEINASE fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    METALLOPROTEINASE -->|"target for"| Fibrosis["Fibrosis"]
    METALLOPROTEINASE -->|"target for"| Als["Als"]
    METALLOPROTEINASE -->|"activates"| Aging["Aging"]
    METALLOPROTEINASE -->|"activates"| Ischemia["Ischemia"]
    METALLOPROTEINASE -->|"activates"| Stroke["Stroke"]
    METALLOPROTEINASE -.->|"biomarker for"| Cancer["Cancer"]
    METALLOPROTEINASE -->|"contributes to"| Dementia["Dementia"]
    METALLOPROTEINASE -->|"contributes to"| Alzheimer["Alzheimer"]
    IGF1R([IGF1R]) -->|"target for"| METALLOPROTEINASE
    DAG1([DAG1]) -->|"target for"| METALLOPROTEINASE
    RNA([RNA]) -->|"target for"| METALLOPROTEINASE
    HSPG2([HSPG2]) -->|"target for"| METALLOPROTEINASE
    STROKE([STROKE]) -->|"activates"| METALLOPROTEINASE
    MMP9([MMP9]) -->|"activates"| METALLOPROTEINASE
    AEP([AEP]) -->|"activates"| METALLOPROTEINASE
    TRKB([TRKB]) -->|"activates"| METALLOPROTEINASE
    AGING([AGING]) -->|"activates"| METALLOPROTEINASE
    MMP2([MMP2]) -->|"activates"| METALLOPROTEINASE

Outgoing (55)

Target	Relation	Type	Str
Fibrosis	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Fibrosis	activates	disease	0.60
Alzheimer	biomarker_for	disease	0.60
Atherosclerosis	expressed_in	disease	0.60
Als	expressed_in	disease	0.60
Aging	activates	disease	0.60
Ischemia	activates	disease	0.60
Stroke	activates	disease	0.60
Als	biomarker_for	disease	0.60
Atherosclerosis	activates	disease	0.60
Senescence	associated_with	disease	0.60
Parkinson	activates	disease	0.60
Alzheimer	activates	disease	0.60
Aging	biomarker_for	disease	0.60
Cancer	biomarker_for	disease	0.60
Aging	expressed_in	disease	0.60
Lymphoma	activates	disease	0.60
Cancer	inhibits	disease	0.60
Hypertension	activates	disease	0.60
Aging	causes	disease	0.60
Neuroinflammation	activates	disease	0.60
Alzheimer	causes	disease	0.60
Als	causes	disease	0.60
Schizophrenia	expressed_in	disease	0.60
Alzheimer	expressed_in	disease	0.60
Cancer	expressed_in	disease	0.60
Als	activates	disease	0.60
Alzheimer	contributes_to	disease	0.60
Aging	contributes_to	disease	0.60
Als	contributes_to	disease	0.60
Huntington	contributes_to	disease	0.60
Dementia	contributes_to	disease	0.60
Ferroptosis	activates	disease	0.60
Blood-Brain Barrier	contributes_to	pathway	0.55
Inflammasome	expressed_in	pathway	0.55
Mapk	expressed_in	pathway	0.55
Autophagy	activates	pathway	0.55
Mtor	activates	pathway	0.55
Nf-Κb	expressed_in	pathway	0.55
Immune Response	associated_with	pathway	0.55
Toll-Like Receptor	regulates	pathway	0.55
Oxidative Stress	activates	pathway	0.55
Mapk	activates	pathway	0.55
Apoptosis	inhibits	pathway	0.55
Immune Response	activates	pathway	0.55
Apoptosis	activates	pathway	0.55
Nf-Κb	activates	pathway	0.55
Nf-Κb	associated_with	pathway	0.55
Pi3K/Akt	expressed_in	pathway	0.55

Incoming (97)

Source	Relation	Type	Str
CYTOKINES	therapeutic_target	gene	0.60
ALZHEIMER	contributes_to	gene	0.60
DEMENTIA	contributes_to	gene	0.60
PERICYTE	activates	gene	0.60
TAU	activates	gene	0.60
HUNTINGTON	contributes_to	gene	0.60
APOE4	activates	gene	0.60
MMP1	activates	gene	0.60
GPX4	activates	gene	0.60
P53	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
SLC7A11	activates	gene	0.60
SOX9	activates	gene	0.60
ROS	activates	gene	0.60
MMP3	activates	gene	0.60
IL-1	activates	gene	0.60
AKT	activates	gene	0.60
ADAM10	inhibits	gene	0.60
NLGN3	inhibits	gene	0.60
ERK	activates	gene	0.60
STING	activates	gene	0.60
DNA	activates	gene	0.60
NLRP3	activates	gene	0.60
CGAS	activates	gene	0.60
IL-10	expressed_in	gene	0.60
NLRP3	expressed_in	gene	0.60
CYTOKINES	expressed_in	gene	0.60
IL-1	expressed_in	gene	0.60
IL-6	expressed_in	gene	0.60
APP	activates	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
BACE1	expressed_in	gene	0.60
CHRNA7	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
ASTROCYTES	activates	gene	0.60
AMYLOID	causes	gene	0.60
COMPLEMENT	activates	gene	0.60
ALZHEIMER	causes	gene	0.60
MAPK	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
CYTOKINES	activates	gene	0.60
IL-6	activates	gene	0.60
STROKE	activates	gene	0.60
MMP9	activates	gene	0.60
AEP	activates	gene	0.60
TRKB	activates	gene	0.60
AGING	activates	gene	0.60
MMP2	activates	gene	0.60
MMP9	inhibits	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Matrix Metalloproteinase-9 and TIMP-1 Ratio in Peripheral Bl	0.735	-	What blood-brain barrier permeability ch
Matrix Metalloproteinase-9/TIMP-1 Ratio in CSF Identifies Pr	0.675	-	What blood-brain barrier permeability ch
Matrix Metalloproteinase-9 and TIMP-1 Ratio in Peripheral Bl	0.640	-	What blood-brain barrier permeability ch
Matrix Metalloproteinase-9-Mediated Claudin-5 Cleavage Drive	0.515	-	What blood-brain barrier permeability ch

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning METALLOPROTEINASE in their description or question text

No additional research found