biomarker 1,616 words KG: CSF 2026-03-25
kind:biomarkersection:biomarkersstate:published
Contents

Total Tau (t-tau) in Cerebrospinal Fluid

🔬 Protein Info
Gene SymbolCSF
Sensitivity80-85%
Specificity75-80%
AUC0.80-0.85
Creutzfeldt-Jakob Disease (CJD)Extremely high levels (>10,000 pg/mL)
StrokeAcute elevation
Traumatic Brain Injury (TBI)Acute and chronic elevation
Associated DiseasesMULTIPLE SCLEROSIS
Known Drugs/CompoundsADUCANUMAB
KG Connections122 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.55

Related Analyses (24)

Extracellular vesicle biomarkers for early AD detection
neurodegeneration · completed
Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

Related Experiments (16)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (4)

Tau Consortium
organization · KG edge: expressed_in
Proteome Atlas for Neurodegenerative Diseases
mechanism · KG edge: contains
AQP4 (Aquaporin-4 Gene)
gene · KG edge: loss_affects
Neurodegeneration
disease · KG edge: regulates

Knowledge Graph (12 edges)

CSF contains PROTEOME
CSF contains PD_ProS
CSF activates AQP4
CSF inhibits MELANOMA
CSF associated_with TAU
CSF regulates TAU
CSF interacts_with SYK
CSF activates SYK
CSF stabilizes TAU
CSF produces TAU