disease

MULTIPLE SCLEROSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MULTIPLE SCLEROSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2394Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

4Debates

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Disease Info

Associated Genes	AB, ACHE, AD, AKT, ALOX5, AMPK, AMYLOID, amyotrophic lateral sclerosis
Therapeutic Agents	DIMETHYL FUMARATE, METFORMIN
KG Connections	724 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"] -->|"associated"| OLIGODENDROCYTE["OLIGODENDROCYTE"]
    MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"] -->|"regulates"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"] -->|"contributes to"| NEURODEGENERATION["NEURODEGENERATION"]
    MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"] -->|"protects against"| NEURODEGENERATION_1["NEURODEGENERATION"]
    MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"] -->|"treats"| NEUROINFLAMMATION_2["NEUROINFLAMMATION"]
    MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"] -->|"treats"| RIPK1["RIPK1"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated"| MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"]
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"associated"| MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"]
    ALS["ALS"] -->|"associated"| MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"]
    MICROGLIA["MICROGLIA"] -->|"associated"| MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"]
    style MULTIPLE_SCLEROSIS fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (751)

Target	Relation	Type	Str
Inflammation	activates	disease	1.00
Alzheimer	activates	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Inflammation	associated_with	disease	1.00
Neuroinflammation	activates	disease	1.00
Neurodegeneration	therapeutic_target	disease	1.00
Alzheimer	associated_with	disease	1.00
Stroke	associated_with	disease	1.00
Neurodegeneration	regulates	disease	1.00
Neurodegeneration	activates	disease	1.00
Inflammation	regulates	disease	1.00
Neuroinflammation	therapeutic_target	disease	1.00
Immune Response	therapeutic_target	pathway	1.00
Oxidative Stress	therapeutic_target	pathway	1.00
Blood-Brain Barrier	therapeutic_target	pathway	1.00
Demyelination	associated_with	process	0.95
Alzheimer	regulates	disease	0.95
Axonal Loss	causes	process	0.95
Inflammation	causes	disease	0.95
Axonal Damage	causes	phenotype	0.95
Central Nervous System	associated_with	cell_type	0.95
Demyelinating Disease	associated_with	process	0.95
Myelin Loss	causes	phenotype	0.95
oligodendrocytes	affects	cell_type	0.90
Autoimmune Response	causes	process	0.90
Periventricular T2 Lesion	biomarker_for	biomarker	0.90
blood-brain barrier	involves	pathway	0.90
Acute Injury	associated_with	process	0.90
astrocytes	affects	cell_type	0.90
Brain Inflammation	causes	process	0.90
Dawson'S Finger	biomarker_for	biomarker	0.90
microglia	affects	cell_type	0.90
Demyelination	causes	phenotype	0.90
Oligodendrocyte	causes	cell_type	0.90
Axonal Loss	associated_with	phenotype	0.90
Oligodendrocyte	regulates	cell_type	0.90
Neuronal Cell Death	causes	phenotype	0.90
oxidative stress response	involves	pathway	0.90
Neuroaxonal Injury	causes	phenotype	0.90
neurons	affects	cell_type	0.90
Brain T1 Hypointensity	biomarker_for	biomarker	0.90
white matter	affects	brain_region	0.90
Blood-Brain Barrier	causes	process	0.90
Neurodegeneration	causes	process	0.90
Visual System Degeneration	causes	phenotype	0.90
spinal cord	affects	brain_region	0.90
Visual Pathway Degeneration	causes	process	0.90
Blood-Brain Barrier	activates	pathway	0.90
Immune Response	regulates	pathway	0.90

Incoming (1643)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
ALZHEIMER	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
ALZHEIMER	regulates	gene	1.00
IL-6	associated_with	gene	1.00
Parkinson	activates	disease	1.00
AMYLOID	associated_with	protein	1.00
Als	causes	disease	1.00
ALS	associated_with	disease	1.00
PARKINSON'S DISEASE	activates	gene	1.00
PARKINSON	activates	gene	1.00
STROKE	associated_with	gene	1.00
Parkinson	associated_with	disease	1.00
INFLAMMATION	regulates	gene	1.00
ASTROCYTES	associated_with	cell_type	1.00
MICROGLIA	associated_with	cell_type	1.00
NEURODEGENERATION	regulates	gene	1.00
CYTOKINES	activates	gene	1.00
Als	associated_with	disease	1.00
MICROGLIA	activates	gene	1.00
astrocyte	associated_with	cell_type	1.00
NEURODEGENERATION	associated_with	gene	1.00
NEURODEGENERATION	activates	gene	1.00
Als	therapeutic_target	disease	1.00
Amyotrophic Lateral Sclerosis	associated_with	disease	1.00
NF-KB	associated_with	protein	1.00
INFLAMMATION	activates	gene	1.00
NEURODEGENERATIVE DISEASES	associated_with	gene	1.00
INFLAMMATION	associated_with	gene	1.00
Als	activates	disease	1.00
NEUROINFLAMMATION	activates	gene	1.00
INFLAMMATION	causes	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	1.00
NEURODEGENERATION	therapeutic_target	gene	1.00
NEURODEGENERATION	causes	gene	1.00
ALZHEIMER	activates	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
PI3K	associated_with	gene	1.00
TNF	associated_with	gene	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	1.00
OXIDATIVE STRESS	therapeutic_target	gene	1.00
AKT	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
PARKINSON	associated_with	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
ASTROCYTES	activates	gene	1.00
NEUROINFLAMMATION	therapeutic_target	gene	1.00
ALZHEIMER'S DISEASE	activates	disease	0.98
TAU	associated_with	protein	0.98