Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Melanoma: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | MIRNAS, DNA, CANCER, GENES, INFLAMMATION, ASC, AIM2, TLR |
| Therapeutic Agents | Anti-Pd-1 Therapy |
| KG Connections | 529 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Melanoma["<b>Melanoma</b>"]
Cancer{"Cancer"}
Melanoma -->|"associated_with"| Cancer
Als{"Als"}
Melanoma -->|"associated_with"| Als
Mapk["Mapk"]
Melanoma -->|"therapeutic_target"| Mapk
AKT(["AKT"])
AKT -->|"therapeutic_target"| Melanoma
CANCER(["CANCER"])
CANCER -->|"associated_with"| Melanoma
GENES(["GENES"])
GENES -->|"associated_with"| Melanoma
Tumor{"Tumor"}
Tumor -->|"associated_with"| Melanoma
style Melanoma fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | associated_with | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Mapk | therapeutic_target | pathway | 1.00 |
| Cancer | therapeutic_target | disease | 0.95 |
| White Population | associated_with | phenotype | 0.95 |
| Cell Cycle | therapeutic_target | pathway | 0.90 |
| Als | inhibits | disease | 0.85 |
| Inflammasome | activates | pathway | 0.80 |
| Metastasis | activates | pathway | 0.80 |
| Differentiation | therapeutic_target | pathway | 0.80 |
| Inflammation | activates | disease | 0.75 |
| Cancer | inhibits | disease | 0.75 |
| Lung Cancer | associated_with | disease | 0.75 |
| Pi3K/Akt | therapeutic_target | pathway | 0.70 |
| Metastasis | associated_with | pathway | 0.70 |
| Immunotherapy | inhibits | pathway | 0.70 |
| Receptor Tyrosine Kinase | therapeutic_target | pathway | 0.70 |
| Autophagy | therapeutic_target | pathway | 0.70 |
| Tumor Microenvironment | associated_with | pathway | 0.70 |
| Immunotherapy | therapeutic_target | pathway | 0.70 |
| Invasion | activates | pathway | 0.70 |
| Apoptosis | therapeutic_target | pathway | 0.70 |
| Apoptosis | activates | pathway | 0.70 |
| Metastasis | therapeutic_target | pathway | 0.70 |
| Metastasis | inhibits | pathway | 0.70 |
| Erk Signaling | therapeutic_target | pathway | 0.70 |
| Immune Checkpoint | therapeutic_target | pathway | 0.70 |
| Carcinoma | associated_with | disease | 0.65 |
| Alzheimer | inhibits | disease | 0.65 |
| Infection | activates | disease | 0.65 |
| Bacterial Infection | activates | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Carcinoma | inhibits | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Cancer | implicated_in | disease | 0.65 |
| Colorectal Cancer | activates | disease | 0.65 |
| Mtor | treats | pathway | 0.60 |
| Dna Methylation | associated_with | pathway | 0.60 |
| Dna Repair | associated_with | pathway | 0.60 |
| Mitophagy | inhibits | pathway | 0.60 |
| Toll-Like Receptor | associated_with | pathway | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Autophagy | inhibits | pathway | 0.60 |
| Immune Response | inhibits | pathway | 0.60 |
| Ubiquitin-Proteasome | therapeutic_target | pathway | 0.60 |
| Apoptosis | associated_with | pathway | 0.60 |
| Invasion | associated_with | pathway | 0.60 |
| Angiogenesis | associated_with | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AKT | therapeutic_target | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| GENES | associated_with | gene | 1.00 |
| Tumor | associated_with | disease | 1.00 |
| CANCER | activates | gene | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| ERK | therapeutic_target | gene | 1.00 |
| PI3K | therapeutic_target | gene | 0.95 |
| Braf-V600E | associated_with | biomarker | 0.90 |
| Tumor | inhibits | disease | 0.85 |
| Cancer | therapeutic_target | disease | 0.85 |
| Cancer | associated_with | disease | 0.85 |
| CANCER | inhibits | gene | 0.85 |
| Anti-Pd-1 Therapy | treats | drug | 0.85 |
| TCR diversity | associated_with | phenotype | 0.80 |
| ALZHEIMER | inhibits | gene | 0.75 |
| ALZHEIMER'S DISEASE | inhibits | gene | 0.75 |
| INFLAMMATION | activates | gene | 0.75 |
| IL6 | associated_with | gene | 0.75 |
| AIM2 | activates | gene | 0.75 |
| BCL-2 | therapeutic_target | gene | 0.75 |
| AUTOPHAGY | therapeutic_target | gene | 0.75 |
| PARKINSON'S DISEASE | associated_with | gene | 0.75 |
| PARKINSON | associated_with | gene | 0.75 |
| Tumor | activates | disease | 0.75 |
| Cancer | activates | disease | 0.75 |
| APOPTOSIS | therapeutic_target | gene | 0.75 |
| APOPTOSIS | activates | gene | 0.75 |
| GENES | activates | gene | 0.75 |
| BRAF | associated_with | gene | 0.75 |
| DNA | causes | gene | 0.75 |
| ERK | activates | gene | 0.75 |
| CANCER | regulates | gene | 0.75 |
| ERK | inhibits | gene | 0.75 |
| OVERVIEW | therapeutic_target | gene | 0.75 |
| ERK1 | therapeutic_target | gene | 0.75 |
| CANCER | implicated_in | gene | 0.75 |
| AKT | regulates | gene | 0.75 |
| CDK4 | associated_with | gene | 0.75 |
| POT1 | associated_with | gene | 0.75 |
| JNK | therapeutic_target | gene | 0.75 |
| P38 | therapeutic_target | gene | 0.75 |
| APAF1 | biomarker_for | protein | 0.70 |
| INFLAMMATION | therapeutic_target | gene | 0.65 |
| MTOR | treats | gene | 0.65 |
| MIRNAS | associated_with | gene | 0.65 |
| DNA | associated_with | gene | 0.65 |
| INFLAMMATION | associated_with | gene | 0.65 |
| MITOPHAGY | inhibits | gene | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||