concept

NEUROFILAMENT LIGHT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEUROFILAMENT LIGHT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

66Connections

2Hypotheses

0Analyses

47Outgoing

19Incoming

0Experiments

0Debates

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💡 Concept Info

Name	NEUROFILAMENT LIGHT
Key Genes/Proteins	AMYLOID, AMYLOID-BETA, APOE, AQP4, BDNF, GDNF
Related Diseases	ALS, ALZHEIMER, AUTOPHAGY, AXONAL DEGENERATION, CEREBROSPINAL FLUID

Pathway Diagram

graph TD
    NEUROFILAMENT_LIGHT[NEUROFILAMENT LIGHT]
    NEUROFILAMENT_LIGHT -.biomarker for.-> Neurodegeneration[Neurodegeneration]
    NEUROFILAMENT_LIGHT -.biomarker for.-> All_Cause_Dementia[All-Cause Dementia]
    NEUROFILAMENT_LIGHT -->|phosphorylates| ALS[ALS]
    NEUROFILAMENT_LIGHT -->|interacts| AMYLOID[AMYLOID]
    NEUROFILAMENT_LIGHT -->|produces| INFLAMMATION[INFLAMMATION]
    NEUROFILAMENT_LIGHT -->|phosphorylates| TAU[TAU]
    NEUROFILAMENT_LIGHT -.biomarker for.-> NEURON[NEURON]
    Strem2[Strem2] -->|correlates_with| NEUROFILAMENT_LIGHT
    Cryptic_Hdgfl2[Cryptic Hdgfl2] -->|correlates_with| NEUROFILAMENT_LIGHT
    Cryptic_HDGFL2_Levels[Cryptic HDGFL2 Levels] -->|correlates_with| NEUROFILAMENT_LIGHT
    Alzheimer_s_Disease[Alzheimer's Disease] -.biomarker for.-> NEUROFILAMENT_LIGHT
    ALS -->|regulates| NEUROFILAMENT_LIGHT
    TAU -->|stabilizes| NEUROFILAMENT_LIGHT
    BDNF[BDNF] -->|treats| NEUROFILAMENT_LIGHT
    CSF[CSF] -->|synergizes_with| NEUROFILAMENT_LIGHT

Outgoing (47)

Target	Relation	Type	Str
Neurodegeneration	biomarker_for	process	0.92
All-Cause Dementia	biomarker_for	disease	0.80
INFLAMMATION	associated_with	phenotype	0.65
AMYLOID	interacts_with	protein	0.65
ALS	phosphorylates	disease	0.65
Alzheimer's Disease	associated_with	disease	0.65
NEURON	associated_with	cell_type	0.60
TAU	protects_against	protein	0.60
TAU	biomarker_for	protein	0.60
TAU	phosphorylates	protein	0.60
ALS	treats	disease	0.60
NEURON	protects_against	cell_type	0.60
ALS	biomarker_for	disease	0.60
NEURON	biomarker_for	cell_type	0.60
CORPUS CALLOSUM	associated_with	brain_region	0.50
AUTOPHAGY	associated_with	phenotype	0.50
LIPID METABOLISM	associated_with	phenotype	0.50
NEURONS	associated_with	cell_type	0.50
CORTEX	associated_with	brain_region	0.50
WHITE MATTER	associated_with	brain_region	0.50
MYELOID CELLS	associated_with	cell_type	0.50
AMYLOID-BETA	associated_with	protein	0.50
MICROGLIA	associated_with	cell_type	0.50
AQP4	associated_with	gene	0.50
TDP-43	associated_with	gene	0.50
P2X7	associated_with	gene	0.50
PROTEIN CLEARANCE	associated_with	phenotype	0.50
SOD1	associated_with	gene	0.50
APOE	associated_with	gene	0.50
BDNF	associated_with	gene	0.50
GDNF	associated_with	gene	0.50
NEUROINFLAMMATION	associated_with	phenotype	0.45
IL6	associated_with	gene	0.45
IL18	associated_with	gene	0.45
IL10	associated_with	gene	0.45
TREM2	associated_with	gene	0.45
CSF	associated_with	phenotype	0.45
AMYLOID	associated_with	protein	0.45
NEURODEGENERATION	associated_with	phenotype	0.45
ALS	associated_with	disease	0.45
TAU	associated_with	protein	0.45
PHOSPHO-TAU	associated_with	protein	0.45
ALZHEIMER	associated_with	disease	0.45
P-TAU	associated_with	protein	0.45
GFAP	associated_with	gene	0.45
UBIQUITIN	associated_with	protein	0.45
CYTOKINES	associated_with	phenotype	0.45

Incoming (19)

Source	Relation	Type	Str
Strem2	correlates_with	protein	0.92
Cryptic Hdgfl2	correlates_with	biomarker	0.88
Cryptic HDGFL2 Levels	correlates_with	biomarker	0.85
Alzheimer's Disease	biomarker_for	disease	0.85
Neuronal Injury	associated_with	process	0.80
Diabetes	associated_with	disease	0.79
Hypertension	associated_with	disease	0.79
ALS	regulates	disease	0.65
CEREBROSPINAL FLUID	stabilizes	phenotype	0.60
TAU	stabilizes	protein	0.60
TAU	regulates	protein	0.60
TAU	treats	protein	0.60
CSF	synergizes_with	phenotype	0.60
CSF	regulates	phenotype	0.60
BDNF	treats	gene	0.60
NEURON	expressed_in	cell_type	0.55
MICROGLIAL ACTIVATION	associated_with	phenotype	0.50
CEREBROSPINAL FLUID	associated_with	phenotype	0.45
AXONAL DEGENERATION	associated_with	phenotype	0.45

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CSF Neurofilament Light Chain-Guided Astrocyte-Derived Extra	0.458	molecular-neurobiology	How does lncRNA-0021 achieve sequence-sp
CSF Neurofilament Light-Triggered Astrocyte-Derived Exosome	0.450	molecular-neurobiology	How does lncRNA-0021 achieve sequence-sp

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NEUROFILAMENT LIGHT in their description or question text

No additional research found