Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NEUROFILAMENT LIGHT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| ALS | phosphorylates | disease | 0.65 |
| AMYLOID | interacts_with | protein | 0.65 |
| INFLAMMATION | produces | phenotype | 0.65 |
| TAU | phosphorylates | protein | 0.60 |
| TAU | biomarker_for | protein | 0.60 |
| TAU | protects_against | protein | 0.60 |
| NEURON | biomarker_for | cell_type | 0.60 |
| NEURON | protects_against | cell_type | 0.60 |
| NEURON | exacerbates | cell_type | 0.60 |
| ALS | biomarker_for | disease | 0.60 |
| ALS | treats | disease | 0.60 |
| TDP-43 | associated_with | gene | 0.50 |
| P2X7 | associated_with | gene | 0.50 |
| PROTEIN CLEARANCE | associated_with | phenotype | 0.50 |
| SOD1 | associated_with | gene | 0.50 |
| APOE | associated_with | gene | 0.50 |
| BDNF | associated_with | gene | 0.50 |
| AQP4 | associated_with | gene | 0.50 |
| GDNF | associated_with | gene | 0.50 |
| LIPID METABOLISM | associated_with | phenotype | 0.50 |
| NEURON | associated_with | cell_type | 0.50 |
| NEURONS | associated_with | cell_type | 0.50 |
| CORTEX | associated_with | brain_region | 0.50 |
| WHITE MATTER | associated_with | brain_region | 0.50 |
| MYELOID CELLS | associated_with | cell_type | 0.50 |
| AMYLOID-BETA | associated_with | protein | 0.50 |
| CORPUS CALLOSUM | associated_with | brain_region | 0.50 |
| MICROGLIA | associated_with | cell_type | 0.50 |
| AUTOPHAGY | associated_with | phenotype | 0.50 |
| UBIQUITIN | associated_with | protein | 0.45 |
| GFAP | associated_with | gene | 0.45 |
| TAU | associated_with | protein | 0.45 |
| CSF | associated_with | phenotype | 0.45 |
| TREM2 | associated_with | gene | 0.45 |
| IL10 | associated_with | gene | 0.45 |
| IL18 | associated_with | gene | 0.45 |
| IL6 | associated_with | gene | 0.45 |
| P-TAU | associated_with | protein | 0.45 |
| AMYLOID | associated_with | protein | 0.45 |
| NEURODEGENERATION | associated_with | phenotype | 0.45 |
| ALS | associated_with | disease | 0.45 |
| PHOSPHO-TAU | associated_with | protein | 0.45 |
| ALZHEIMER | associated_with | disease | 0.45 |
| CYTOKINES | associated_with | phenotype | 0.45 |
| NEUROINFLAMMATION | associated_with | phenotype | 0.45 |
| INFLAMMATION | associated_with | phenotype | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ALS | regulates | disease | 0.65 |
| TAU | stabilizes | protein | 0.60 |
| TAU | regulates | protein | 0.60 |
| TAU | treats | protein | 0.60 |
| BDNF | treats | gene | 0.60 |
| CSF | synergizes_with | phenotype | 0.60 |
| CSF | regulates | phenotype | 0.60 |
| CEREBROSPINAL FLUID | stabilizes | phenotype | 0.60 |
| NEURON | expressed_in | cell_type | 0.55 |
| MICROGLIAL ACTIVATION | associated_with | phenotype | 0.50 |
| CEREBROSPINAL FLUID | associated_with | phenotype | 0.45 |
| AXONAL DEGENERATION | associated_with | phenotype | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||