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cell 866 words KG: MICROGLIA
Contents

Surveying Microglia

🧫 Cell Type Info
Cell TypeMICROGLIA
Also Known AsMicroglial cells, Brain-resident macrophages
DefinitionResident immune cells of the central nervous system derived from yolk sac progenitors
FunctionsImmune surveillance, Synaptic pruning, Phagocytosis, Cytokine production, Debris clearance
Key MarkersIBA1, CD11b, CX3CR1, P2RY12, TMEM119, TREM2
StatesHomeostatic, Disease-associated (DAM), Activated, Phagocytic, Senescent
Key PathwaysTREM2-DAP12 signaling, TLR4-NF-kB, CSF1R signaling, Complement cascade, cGAS-STING
Associated DiseasesAlzheimer's disease, Parkinson's disease, Multiple sclerosis, ALS, Nasu-Hakola disease
DiscoveryFirst described by Pío del Río Hortega in 1919
Linked Hypotheses294 hypotheses

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Knowledge Graph

Related Hypotheses (21)

TREM2-mediated microglial tau clearance enhancement
Score: 0.80Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.74TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66Smartphone-Detected Motor Variability Correction
Score: 0.74

Related Analyses (18)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedSenolytic therapy for age-related neurodegeneration
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedMechanistic role of APOE in neurodegeneration
neurodegeneration · archived

Related Experiments (7)

Longitudinal TLR2 reporter gene study in α-synuclein mice
validation · proposed · Score: 0.90Dexamethasone treatment study in α-synuclein mice
validation · proposed · Score: 0.85TLR expression in α-synuclein overexpressing mice
validation · proposed · Score: 0.80TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.40Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40

Knowledge Graph (12 edges)

MICROGLIA associated_with ALZHEIMER'S_DISEASE
MICROGLIA interacts_with BDNF
MICROGLIA interacts_with CD22
MICROGLIA expresses TNF-α
MICROGLIA expresses IL-6
MICROGLIA expresses IL-1β
MICROGLIA expresses ACOD1
MICROGLIA disrupts GLOBE_TIO2_TDCPP_EXPOSURE
MICROGLIA associated_with CHILDHOOD_DEPRIVATION
MICROGLIA modulates SYNAPTIC_PRUNING

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