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Home / Wiki / Clinical: Tolfenamic Acid PSP Trial (NCT04253132)

clinical 2,854 words KG: NCT 2026-03-28

section:clinical-trials kind:clinical-trial topic:psp topic:tauopathy

Contents

Tolfenamic Acid PSP Trial (NCT04253132)

Knowledge Graph

Related Hypotheses (4)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.96 Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.81 Piezoelectric Nanochannel BBB Disruption
Score: 0.66 Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.66

Related Analyses (3)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived 4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · completed Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (21)

4R-Tau Targeting Therapies for PSP and CBS
clinical · proposed · Score: 0.40 Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40 Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri
clinical · proposed · Score: 0.40 Brainstem Circuit Modulation for PSP
clinical · proposed · Score: 0.40 Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40

Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40 Levodopa Response Determinants in PSP — Biomarker-Guided Pre
clinical · proposed · Score: 0.40 Cytochrome Therapeutics
clinical · proposed · Score: 0.40 Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40 Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40 Oligodendrocyte-Myelin Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40 Proteasome-Ubiquitin System Dysfunction Validation in Parkin
clinical · proposed · Score: 0.40 Protein Aggregation Kinetic Validation Results
validation · proposed · Score: 0.40 PSP and CBS Biomarker Validation Study
clinical · proposed · Score: 0.40 Purinergic Signaling Dysfunction Validation in Parkinson's D
clinical · proposed · Score: 0.40 Regulated Necrosis Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40 Stress Granule Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40 Tau Pathology Initiation Zone Identification
clinical · proposed · Score: 0.40 Tau Spreading Network Mapping via Spatial Transcriptomics in
clinical · proposed · Score: 0.40 Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40 SCFA-Mediated Neuroinflammation in Alzheimer's Disease
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

NCT participates_in circadian regulation

NCT activates PSEN

NCT interacts_with neurodegeneration

NCT interacts_with VCP

NCT activates VCP

NCT associated_with Alzheimer

NCT associated_with PS1

NCT activates PS1

NCT interacts_with Alzheimer's disease

NCT participates_in ubiquitin-proteasome

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