Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about circadian regulation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| CLOCK | participates_in | gene | 0.85 |
| BMAL1 | participates_in | gene | 0.85 |
| neuroinflammation | involves | disease | 0.85 |
| CRY1 | participates_in | gene | 0.85 |
| neurons | active_in | cell_type | 0.85 |
| Alzheimer's disease | involves | disease | 0.85 |
| PER1 | participates_in | gene | 0.75 |
| neurodegeneration | involves | disease | 0.75 |
| ARNT | participates_in | gene | 0.75 |
| SIRT1 | participates_in | gene | 0.75 |
| TNF | participates_in | gene | 0.75 |
| PER2 | participates_in | gene | 0.75 |
| astrocytes | active_in | cell_type | 0.75 |
| PER | participates_in | gene | 0.75 |
| stem cells | active_in | cell_type | 0.75 |
| DNA | participates_in | gene | 0.75 |
| microglia | active_in | cell_type | 0.75 |
| REV | participates_in | gene | 0.75 |
| MTNR1A | participates_in | gene | 0.65 |
| MTNR1B | participates_in | gene | 0.65 |
| MT1 | participates_in | gene | 0.65 |
| AQP4 | participates_in | gene | 0.65 |
| LRP1 | participates_in | gene | 0.65 |
| ATG5 | participates_in | gene | 0.65 |
| LC3 | participates_in | gene | 0.65 |
| ATG7 | participates_in | gene | 0.65 |
| BECN1 | participates_in | gene | 0.65 |
| nicotinamide | modulates | drug | 0.65 |
| CRY2 | participates_in | gene | 0.65 |
| GFAP | participates_in | gene | 0.65 |
| TET2 | participates_in | gene | 0.65 |
| ALS | participates_in | gene | 0.65 |
| Parkinson's disease | involves | disease | 0.65 |
| DAM microglia | active_in | cell_type | 0.65 |
| AMPK | participates_in | gene | 0.65 |
| NAD | participates_in | gene | 0.65 |
| RNA | participates_in | gene | 0.65 |
| CRY | participates_in | gene | 0.65 |
| DDC | participates_in | gene | 0.55 |
| APP | participates_in | gene | 0.55 |
| PP2A | participates_in | gene | 0.55 |
| NR3C1 | participates_in | gene | 0.55 |
| TNFA | participates_in | gene | 0.55 |
| FKBP5 | participates_in | gene | 0.55 |
| ADRA2A | participates_in | gene | 0.55 |
| ULK1 | participates_in | gene | 0.55 |
| MAP1LC3B | participates_in | gene | 0.55 |
| TDP-43 | participates_in | gene | 0.55 |
| HSF1 | participates_in | gene | 0.55 |
| tauopathy | involves | disease | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||