gene 916 words KG: NCT 2026-03-24
kind:genesection:genesstate:published
Contents

NCT (Nicastrin) Gene

🧬 Gene Info
Gene SymbolNCT
Full NameNicastrin
Chromosome1p31.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization) modifies this processivity context with presenilin variants, creating an interaction layer between genetic background
Pathwayscircadian regulation
UniProt IDQ92542
NCBI Gene ID51594
Ensembl IDENSG00000103546
GeneCardsNCT
Human Protein AtlasNCT
Primary Disease LinksAlzheimer's disease, Parkinson's disease
Associated DiseasesAlzheimer
InteractionsPSEN, VCP, PS1, TAU, APH1, APP
KG Connections15 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (14)

SASP-Mediated Cholinergic Synapse Disruption
Score: 0.56
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.49
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Lysosomal Enzyme Trafficking Correction
Score: 0.49
Lysosomal Membrane Repair Enhancement
Score: 0.45

Related Analyses (5)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Microglial subtypes in neurodegeneration — friend vs foe
neuroscience · failed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 9 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 9 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 9 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 9 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 9 hypotheses

Knowledge Graph (12 edges)

NCT participates_in circadian regulation
NCT activates PSEN
NCT interacts_with neurodegeneration
NCT interacts_with VCP
NCT activates VCP
NCT associated_with Alzheimer
NCT associated_with PS1
NCT activates PS1
NCT interacts_with Alzheimer's disease
NCT participates_in ubiquitin-proteasome