gene 874 words KG: APH1 2026-03-24
kind:genesection:genesstate:published
Contents

APH1A Gene

🧬 Gene Info
Gene SymbolAPH1A, APH1B
Full NameAPH1A
AliasesAPH1, aph1
Protein FamilyAPH-1 family (γ-secretase complex)
Protein TypeGene
FunctionComplex Formation Initiation: APH-1 binds to presenilin in the ER, initiating complex assembly
Primary ExpressionEndoplasmic reticulum, Golgi apparatus, plasma membrane
Molecular Weight35 kDa
Amino Acids346 aa
UniProt IDQ9WVM4
NCBI Gene IDSearch NCBI
Associated DiseasesAlzheimer's Disease, Frontotemporal Dementia
InteractionsNCT, PSEN, PSEN1, Gamma-Secretase Complex, ALZHEIMER'S DISEASE, NEURON
KG Connections30 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Glial Glycocalyx Remodeling Therapy
Score: 0.41

Related Analyses (4)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: contributes_to
NCSTN Gene - Nicastrin
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

APH1 contributes_to STAT3
APH1 expressed_in NCSTN
APH1 expressed_in MYC
APH1 interacts_with Gamma-Secretase Complex
APH1 activates NCT
APH1 activates PSEN
APH1 interacts_with PSEN
APH1 interacts_with PSEN1
APH1 associated_with APP
APH1 associated_with STAT3