trial 2,127 words KG: Urolithin A 2026-03-28
section:clinical-trialskind:trialdisease:parkinsonsintervention:urolithin-aphase:phase-2
Contents

Urolithin A for Parkinson's Disease (MUSIC Trial NCT06033890)

Knowledge Graph

Related Hypotheses (9)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
APOE-Dependent Autophagy Restoration
Score: 0.63
Senescent Cell Mitochondrial DNA Release
Score: 0.54
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.51

Related Analyses (20)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (30)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.40
AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40
Alpha-Synuclein SAA Kinetics Study — Biological Staging Back
clinical · proposed · Score: 0.40

See Also (7)

Neuroprotection Strategies in Neurodegeneration
therapeutic · KG edge: mediates
Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: promotes
NLRP3 Inflammasome Hypothesis in Parkinson's Disease
hypothesis · KG edge: inhibits
RANKL (TNFSF11)
gene · KG edge: inhibits
CTSZ Gene - Cathepsin Z
gene · KG edge: regulates

Knowledge Graph (12 edges)

Urolithin A associated_with Lysosomal function
Urolithin A inhibits Amyloidogenesis
Urolithin A modulates TGM2
Urolithin A inhibits Mitochondrial ROS Accumulation
Urolithin A modulates Calcium Homeostasis
Urolithin A associated_with Cognition
Urolithin A associated_with Lysosomal Function
Urolithin A restores lysosomal function
Urolithin A suppresses Amyloidogenesis
Urolithin A mediates Neuroprotection