concept

NF-KB PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NF-KB PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

2Analyses

18Outgoing

11Incoming

0Experiments

2Debates

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💡 Concept Info

Name	NF-KB PATHWAY
Key Genes/Proteins	AMYLOID, JAK2, MAPK, STAT1, STAT3, STING
Related Diseases	AGING, GLIOSIS, INFLAMMATION, NEUROINFLAMMATION, OXIDATIVE STRESS

Pathway Diagram

graph TD
    NF_KB_PATHWAY[NF-KB PATHWAY]
    NF_KB_PATHWAY -->|activates| Microglia[Microglia]
    NF_KB_PATHWAY -->|causes| TNF[TNF]
    NF_KB_PATHWAY -->|causes| NEUROINFLAMMATION[NEUROINFLAMMATION]
    Urolithin_A[Urolithin A] -->|inhibits| NF_KB_PATHWAY
    RIPK2[RIPK2] -->|activates| NF_KB_PATHWAY
    NRF2[NRF2] -->|regulates| NF_KB_PATHWAY
    STING[STING] -->|activates| NF_KB_PATHWAY
    MICROGLIA[MICROGLIA] -->|activates| NF_KB_PATHWAY
    STAT1[STAT1] -->|implicated in| NF_KB_PATHWAY

Outgoing (18)

Target	Relation	Type	Str
Immune Evasion	associated_with	process	0.80
Microglia	activates	cell_type	0.70
Pro-inflammatory cytokine release	activates	process	0.70
NEUROINFLAMMATION	causes	phenotype	0.65
TNF	causes	gene	0.65
TNF	inhibits	gene	0.65
STAT1	associated_with	gene	0.45
MICROGLIA	associated_with	cell_type	0.45
UBIQUITIN	associated_with	protein	0.45
STING	associated_with	gene	0.45
TNF	associated_with	gene	0.45
STAT3	associated_with	gene	0.45
JAK2	associated_with	gene	0.45
AMYLOID	associated_with	protein	0.45
AGING	associated_with	phenotype	0.45
MAPK	associated_with	gene	0.45
GLIOSIS	associated_with	phenotype	0.45
INFLAMMATION	associated_with	phenotype	0.45

Incoming (11)

Source	Relation	Type	Str
RIPK2	activates	protein	0.90
Urolithin A	inhibits	drug	0.90
RIPK2	activates	protein	0.85
NRF2	regulates	protein	0.80
cGAS/STING	activates	pathway	0.70
MICROGLIA	activates	cell_type	0.65
STING	activates	gene	0.65
STAT1	implicated_in	gene	0.55
GPR43 signaling	inhibits	pathway	0.50
NEUROINFLAMMATION	associated_with	phenotype	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Do SCFAs directly modulate α-synuclein aggregation in vivo at physiologically re

neurodegeneration | 2026-04-12 | 2 hypotheses Top: 0.682

What determines the specificity of TDP-43-induced mitochondrial DNA release for

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.720

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

While the study establishes TDP-43 triggers mtDNA release via mPTP to activate c

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

The debate identified a critical mechanistic gap between SCFA production by gut

closed · Rounds: 4 · Score: 0.70 · 2026-04-12

Related Research

Hypotheses and analyses mentioning NF-KB PATHWAY in their description or question text

No additional research found