| Gene Symbol | IL6 |
| Full Name | Interleukin 6 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Pathways | Akt, Amyloid, Apoptosis, Autophagy, Epigenetic |
| Ensembl ID | ENSG00000136244 |
| GeneCards | IL6 |
| Human Protein Atlas | IL6 |
| IL-6R (CD126) | Membrane-bound receptor |
| gp130 (CD130) | Signal-transducing subunit (shared with other IL-6 family cytokines) |
| JAK/STAT3 | Primary signaling pathway |
| MAPK/ERK | Secondary signaling cascade |
| Soluble IL-6R (sIL-6R) | Generated by proteolytic cleavage or alternative splicing |
| Trans-signaling | Enables IL-6 response in cells lacking membrane IL-6R |
| Pro-inflammatory | Trans-signaling is primarily pro-inflammatory |
| Macrophages/Monocytes | Primary source, TLR-stimulated |
| Associated Diseases | AD, ALS, AMI, ATOPIC_DERMATITIS, AUTOIMMUNE_DISEASES, Aging |
| Known Drugs/Compounds | DUPILUMAB, ziltivekimab, IRN, Urolithin A, Andrographis paniculata, SQDS |
| Interactions | IL6R, SREBF1, PSEN2, A2M, DHCR24, HMGCR |
| KG Connections | 2177 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |