concept

CALCIUM HOMEOSTASIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CALCIUM HOMEOSTASIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

0Hypotheses

4Analyses

13Outgoing

35Incoming

0Experiments

5Debates

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💡 Concept Info

Name	CALCIUM HOMEOSTASIS

Pathway Diagram

graph TD
    CALCIUM_HOMEOSTASIS["CALCIUM HOMEOSTASIS"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Neurite_Outgrowth["Neurite Outgrowth"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Synaptogenesis["Synaptogenesis"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Synaptic_Plasticity["Synaptic Plasticity"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Neuronal_Survival["Neuronal Survival"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Synaptic_Dysfunction["Synaptic Dysfunction"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Neuronal_Degeneration["Neuronal Degeneration"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Synaptic_Transmission["Synaptic Transmission"]
    CALCIUM_HOMEOSTASIS -->|"component_of"| Lysosomal_Functions["Lysosomal Functions"]
    Mitochondria["Mitochondria"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    SERCA3["SERCA3"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    PSEN1["PSEN1"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    TRPML1["TRPML1"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    SNCA["SNCA"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    HTT["HTT"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    Energy_Metabolism["Energy Metabolism"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    ER_Mitochondria_Contacts["ER-Mitochondria Contacts"] -->|"regulates"| CALCIUM_HOMEOSTASIS

Outgoing (13)

Target	Relation	Type	Str
Synaptogenesis	regulates	process	0.95
Neuronal Survival	regulates	process	0.95
Neurite Outgrowth	regulates	process	0.95
Synaptic Plasticity	regulates	process	0.95
Synaptic Dysfunction	regulates	phenotype	0.90
Neuronal Degeneration	regulates	phenotype	0.90
Synaptic Transmission	regulates	process	0.90
AMPK	activates	gene	0.85
Lysosomal Functions	component_of	mechanism	0.85
AUTOPHAGY	regulates	process	0.85
Frailty	associated_with	phenotype	0.80
Aging	involved_in	process	0.80
lysosomal function	regulates	process	0.70

Incoming (35)

Source	Relation	Type	Str
Mitochondria	involved_in	cell_type	0.95
Mitochondria	regulates	cell_type	0.95
SERCA3	regulates	protein	0.95
MCOLN1	regulates	gene	0.90
Oxidative Stress	associated_with	process	0.90
Amyloid Beta-Peptide	associated_with	compound	0.90
TRPML1	regulates	protein	0.90
PSEN1	regulates	gene	0.90
Basal Ganglia Calcifications	associated_with	disease	0.88
MITOCHONDRIA	regulates	cell_type	0.88
ER-Mitochondria Contacts	regulates	process	0.85
Energy Metabolism	regulates	process	0.85
SNCA	regulates	gene	0.85
endoplasmic reticulum	involved_in	cell_type	0.85
HTT	regulates	gene	0.85
Oxidative Stress	inhibits	process	0.85
ATP2A3	involved_in	gene	0.85
Aging	involved_in	process	0.85
ion pumps	associated_with	protein	0.85
Endoplasmic Reticulum	regulates	organelle	0.85
Er-Mitochondria Contacts	regulates	process	0.85
CACNA1G	regulates	gene	0.85
amyloid-beta	associated_with	compound	0.80
Urolithin A	modulates	compound	0.80
SNCA	modulates	gene	0.80
SNCA	inhibits	protein	0.80
ANXA11	regulates	gene	0.80
AMYLOID-BETA	inhibits	protein	0.80
APOE	regulates	protein	0.75
SOD1	regulates	protein	0.75
wild-type tau	regulates	protein	0.70
wild_type_tau	regulates	protein	0.70
VDAC1	regulates	gene	0.70
REST	regulates	protein	0.70
ATP2B1	regulates	gene	0.70