concept

AMYLOID BETA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMYLOID BETA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

715Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

5Debates

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💡 Concept Info

Name	AMYLOID BETA
Key Genes/Proteins	ABCA1, Alpha-Synuclein, ALPHA-SYNUCLEIN, ALZHEIMER, AMBRA1, AMPK
Related Diseases	acetylcholine, Alzheimer Disease, Alzheimer's disease, Alzheimer's Disease, Alzheimer'S Disease

Pathway Diagram

graph TD
    AMYLOID_BETA["AMYLOID BETA"]
    AMYLOID_BETA -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
    AMYLOID_BETA -->|"binds"| Microglia["Microglia"]
    AMYLOID_BETA -->|"activates"| Microglial_Activation["Microglial Activation"]
    AMYLOID_BETA -->|"contributes to"| MAP1LC3B["MAP1LC3B"]
    AMYLOID_BETA -->|"contributes to"| SQSTM1["SQSTM1"]
    AMYLOID_BETA -->|"activates"| astrocytes["astrocytes"]
    AMYLOID_BETA -->|"regulates"| autophagy["autophagy"]
    AMYLOID_BETA -->|"causes"| reactive_astrocytes["reactive astrocytes"]
    AMYLOID_BETA -->|"activates"| Autophagy["Autophagy"]
    MAP1LC3B -->|"inhibits"| AMYLOID_BETA
    SQSTM1 -->|"inhibits"| AMYLOID_BETA
    Autophagy -->|"targets"| AMYLOID_BETA
    Intramural_Periarterial_Draina["Intramural Periarterial Drainage"] -->|"involved_in"| AMYLOID_BETA
    Glymphatic_Pathway["Glymphatic Pathway"] -->|"mediates"| AMYLOID_BETA
    Dam["Dam"] -->|"interacts"| AMYLOID_BETA
    SCARA1["SCARA1"] -->|"binds"| AMYLOID_BETA
    AGER["AGER"] -->|"binds"| AMYLOID_BETA
    Lysosomes["Lysosomes"] -->|"involved_in"| AMYLOID_BETA
    CD36["CD36"] -->|"binds"| AMYLOID_BETA
    FPR2["FPR2"] -->|"binds"| AMYLOID_BETA

Outgoing (273)

Target	Relation	Type	Str
Alzheimer'S Disease	contributes_to	disease	0.95
Neuritic Plaques	involved_in	phenotype	0.95
Parkinson's Disease with Dementia	associated_with	disease	0.95
Retinal Degeneration	causes	phenotype	0.95
Alzheimer'S Disease	causes	disease	0.95
Parkinson'S Disease With Dementia	involved_in	disease	0.95
Alzheimer Disease	involved_in	disease	0.95
Neuroinflammation	causes	process	0.95
Alzheimer's Disease	biomarker_for	disease	0.95
Neuritic Plaques	promotes	phenotype	0.95
Alzheimer's Disease	drives	disease	0.95
Alzheimer's Disease	associated_with	disease	0.95
Alzheimer's Disease	contributes_to	disease	0.95
Microglia	activates	cell_type	0.95
ALZHEIMER'S DISEASE	associated_with	disease	0.92
Senile Plaques	contributes_to	phenotype	0.90
Optic Nerve Sheath	transports	cell_type	0.90
Oxidative Stress	causes	process	0.90
Cognitive Decline	contributes_to	phenotype	0.90
Alzheimer Disease	causes	disease	0.90
Microglia	interacts_with	cell_type	0.90
Central Neuroinflammation	causes	process	0.90
SQSTM1	upregulates	gene	0.90
MAP1LC3B	contributes_to	gene	0.90
Alzheimer'S Disease	biomarker_for	disease	0.90
TRKB	degrades	protein	0.90
Alzheimer's Disease	causes	disease	0.90
microglia activation	promotes	process	0.90
LC3B	upregulates	gene	0.90
Striatum	associated_with	brain_region	0.90
Amyloid Plaques	mediates	phenotype	0.90
ASTROCYTE MITOCHONDRIA	localized_to	cell_type	0.90
Retina	expressed_in	cell_type	0.90
SQSTM1	contributes_to	gene	0.90
Microglia Activation	activates	process	0.90
neuroinflammation	promotes	process	0.88
Synaptic Structure	modulates	phenotype	0.88
Synaptic Plasticity	inhibits	process	0.88
Neuron	causes	cell_type	0.85
Visual Impairment	causes	phenotype	0.85
Insulin Resistance	promotes	process	0.85
Neuronal Apoptosis	causes	process	0.85
LRP8	antagonizes	protein	0.85
Alzheimer's Disease Progression	associated_with	process	0.85
Chronic Neuroinflammation	causes	process	0.85
Lysosomal Dysfunction	associated_with	process	0.85
Oligodendrocyte Progenitor Cell Senescence	causes	process	0.85
Apoptosis	causes	process	0.85
Lipid Dyshomeostasis	causes	phenotype	0.85
Insulin Resistance	contributes_to	process	0.85

Incoming (442)

Source	Relation	Type	Str
APP	expresses	gene	1.00
Alzheimer'S Disease	associated_with	disease	0.95
Donanemab	targets	drug	0.95
APP	mediates	protein	0.95
Γ-SECRETASE	cleaves	enzyme	0.95
Anti-Amyloid Beta Therapies	targets	drug	0.95
APP	product_of	protein	0.90
LL37	binds	protein	0.90
Glymphatic System	transports	pathway	0.90
SQSTM1	inhibits	protein	0.90
Hdac Inhibitors	associated_with	drug	0.90
Autophagy	targets	process	0.90
Lyso-Chr2	promotes	protein	0.90
Amyloid-targeting therapy	associated_with	process	0.90
Cerebrospinal Fluid	transports	cell_type	0.90
AQP4	associated_with	gene	0.90
Intramural Periarterial Drainage	involved_in	process	0.90
APP	associated_with	gene	0.90
MAP1LC3B	inhibits	protein	0.90
Ocular Glymphatic System	transports	process	0.90
Amyloid-Related Imaging Abnormalities	associated_with	biomarker	0.90
Disease-Associated Microglia	interacts_with	cell_type	0.90
BACE1	causes	gene	0.90
Autophagy	degrades	process	0.90
D-520	targets	drug	0.90
Microglia	involved_in	cell_type	0.85
Blood-Brain Barrier	transports	brain_region	0.85
APP	regulates	entity	0.85
Defective Insulin Signaling	upregulates	process	0.85
ACE1	associated_with	enzyme	0.85
Hdac Inhibitors	inhibits	drug	0.85
Tirzepatide	inhibits	drug	0.85
Disease-modifying therapy	targets	drug	0.85
Lysosomes	involved_in	cell_type	0.85
Secretases	regulates	enzyme	0.85
PARKIN	interacts_with	gene	0.80
IDE	degrades	protein	0.80
MTOR	enhances	gene	0.80
alpha synuclein	interacts_with	protein	0.80
APOE	interacts_with	gene	0.80
LRP1	regulates	gene	0.80
Microglia	interacts_with	cell_type	0.80
Astrocytes	interacts_with	cell_type	0.80
Hyperbaric Oxygen Therapy	targets	drug	0.80
Mitochondrial Dysfunction	upregulates	process	0.80
Oxidative Stress	upregulates	process	0.80
Microglia	transports	cell_type	0.80
astrocytic autophagy	inhibits	phenotype	0.80
reactive oxygen species	contributes_to	phenotype	0.80
AUTOPHAGY	clears	process	0.80