Contents

Sleep Disorders in Neurodegeneration

Disease Info

Dopaminergic system	Loss of dopaminergic neurons in the substantia nigra and ventral tegmental area disrupts sleep-wake regulation and contributes to restless legs syndrome
Cholinergic system	Degeneration of cholinergic neurons in the basal forebrain and pedunculopontine nucleus impairs arousal and REM sleep generation
Noradrenergic system	Locus coeruleus dysfunction disrupts norepinephrine-mediated arousal and attention
Serotonergic system	Raphe nucleus degeneration affects sleep initiation and maintenance[^14]
Databases	OMIM Orphanet ClinicalTrials PubMed

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