disease 1,306 words KG: ent-dise-1085a2cb
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Voice and Speech in Corticobasal Syndrome

Disease Info
Articulatory errorsInconsistent phonemic distortions, particularly affecting consonant clusters
Groping behaviorVisible searching movements of the lips, tongue, and jaw during speech initiation
Sound substitutionsPhonemic paraphasias (e.g., "table" → "cable")
Prolonged phonemesAbnormal prolongation of consonant sounds
Repeated attemptsMultiple attempts at self-correction
Reduced speech rateOverall slowing of articulation[@johns2023][@du2022]
Premotor cortex (BA6)Damage to lateral premotor regions involved in speech motor planning
Supplementary motor area (SMA)Disruption of sequential speech movements
Left hemisphere predominanceAOS in CBS typically reflects left hemisphere cortical pathology
Reduced vocal loudnessHypophonia, often asymmetric (more affected on the side of motor symptoms)
MonopitchDecreased pitch variation
MonotoneFlat intonation patterns
DatabasesOMIMOrphanetClinicalTrialsPubMed

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Related Hypotheses (3)

Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
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Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed

See Also (15)

Alpha-Synuclein PET Imaging and Biomarker Advances
biomarker · Pages share 3 hypotheses
Alpha-Synuclein Seeding Assays (RT-QuIC and PMCA)
biomarker · Pages share 3 hypotheses
Blood-Based Biomarkers for Neurodegeneration
biomarker · Pages share 3 hypotheses
Blood p-Tau181 and p-Tau217 Elevated in Systemic Amyloi
biomarker · Pages share 3 hypotheses
CSF Biomarkers for Corticobasal Syndrome and Progressiv
biomarker · Pages share 3 hypotheses

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