| Gene Symbol | CSF |
| Elevated in | CBS due to AD pathology, but also elevated in CBS/PSP due to primary tauopathies[@smith2025] |
| Pattern differences | CBS-AD shows higher levels than CBS-PSP, reflecting the greater AD-related neurodegeneration |
| Utility | Non-specific marker of neuronal damage; elevated levels seen in both CBS and PSP but cannot reliably differentiate between underlying pathologies |
| Prognostic value | Higher baseline levels correlate with more rapid clinical progression |
| Longitudinal changes | Annual increases in t-tau predict clinical deterioration in both CBS and PSP |
| Tau oligomers | Elevated in CBS and PSP, reflecting the presence of aggregated tau species |
| Tau seed amplification assays | Can distinguish between different tauopathy subtypes using novel techniques like salt-modulated tau amplification[@classification2026] |
| Tau RT-QuIC | Detects tau seeding activity in CSF, differentiating 4R tauopathies from alpha-synucleinopathies[@ahmad2024] |
| Disease-specific tau strains | Different aggregation properties between CBD/PSP tau and AD tau |
| Associated Diseases | MULTIPLE SCLEROSIS |
| Known Drugs/Compounds | ADUCANUMAB |
| KG Connections | 122 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |