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Entity: C9orf72 Protein (Chromosome 9 Open Reading Frame 72)
entity
636 words
KG: C9orf72
Contents
C9orf72 Protein (Chromosome 9 Open Reading Frame 72)
Knowledge Graph
Related Hypotheses (20)
PARP1 Inhibition Therapy
Score: 0.74
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Vocal Cord Neuroplasticity Stimulation
Score: 0.72
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.71
Autophagosome Maturation Checkpoint Control
Score: 0.71
Cryptic Exon Silencing Restoration
Score: 0.70
Axonal RNA Transport Reconstitution
Score: 0.70
Cross-Seeding Prevention Strategy
Score: 0.69
Lysosomal Membrane Repair Enhancement
Score: 0.69
R-Loop Resolution Enhancement Therapy
Score: 0.68
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Arginine Methylation Enhancement Therapy
Score: 0.65
Nucleolar Stress Response Normalization
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.61
Show 15 more
Related Analyses (10)
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
Show 5 more
Related Experiments (2)
Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study
clinical · proposed · Score: 0.40
See Also (5)
ABCA7 (Redirect)
redirect · KG edge: associated_with
ACTB Gene
gene · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: co_discussed
Knowledge Graph (12 edges)
C9orf72
regulates
MMP9
C9orf72
causes
Frontotemporal dementia
C9orf72
causes
lysosomal dysfunction
C9orf72
regulates
TDP-43
C9orf72
interacts_with
WDR41
C9orf72
involved_in
Autoimmune Response
C9orf72
expressed_in
presynaptic terminals
C9orf72
regulates
dendritic arborization
C9orf72
expressed_in
cerebellum
C9orf72
implicated_in
Purkinje cells
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