gene 1,725 words KG: ACTB 2026-03-27
section:geneskind:genetopic:alzheimerstopic:parkinsonstopic:als
Contents

ACTB Gene

🧬 Gene Info
Gene SymbolACTB
Full NameBeta-Actin
Chromosome7p22.1
Functionis a globular protein with a molecular weight of approximately 42 kDa.
Molecular Weight42 kDa
Exons6
PathwaysAutophagy, Chaperone, Mapk, Mtor, Oxidative Stress
UniProt IDP60709
NCBI Gene ID81
Ensembl IDENSG00000075624
OMIM102630
GeneCardsACTB
Human Protein AtlasACTB
Gene Length5.1 kb
mRNA Length1.3 kb
Associated DiseasesAD, ADH, ALI, AMI, ARM, Als
Known Drugs/Compoundsstatins, rapamycin
InteractionsP2RY12, APOA1, ULK1, ATG5, EIF4EBP1, LC3
KG Connections1101 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Blood-Brain Barrier SPM Shuttle System
Score: 0.55
Autophagosome Maturation Checkpoint Control
Score: 0.49
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49

Related Analyses (9)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (8)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
AKT1 Gene
gene · KG edge: interacts_with
AIF1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ACTB activates CAT
ACTB activates CTSD
ACTB activates EGFR
ACTB activates EIF4EBP1
ACTB activates LRP2
ACTB activates MYC
ACTB activates PIK3C3
ACTB activates PPARA
ACTB activates PPARG
ACTB activates PPARGC1A