gene 757 words KG: KCNQ2
kind:genesection:entitiesstate:publishedtopic:neurodevelopmental-epilepsy
Contents

KCNQ2

🧬 Gene Info
Gene SymbolKCNQ2
AliasesKv7.2
Chromosome20q13.33
Functionis a non-inactivating K+ current that activates at voltages near the threshold for action potential firing.
Primary ExpressionBrain (neurons throughout forebrain, highest in cortex, hippocampus, brainstem)
Molecular Weight95 kDa
Amino Acids844 aa
UniProt IDO43726
NCBI Gene ID3785
Ensembl IDENSG00000155085
OMIM602235
GeneCardsKCNQ2
Human Protein AtlasKCNQ2
Genomic Coordinateschr20:62,030,000-62,100,000 (GRCh38)
Gene Length~50 kb
Associated DiseasesAging
InteractionsEGFR, ERK, RUNX1, CANCER
KG Connections67 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

TDP-43 Cryptic Exon–Targeted ASOs to Restore Hippocampal Gam
Score: 0.58
APOE-Dependent Autophagy Restoration
Score: 0.61
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Hypocretin-Neurogenesis Coupling Therapy
Score: 0.45
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.45

Related Analyses (14)

Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (5)

AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (6)

erk-mapk-signaling-neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: causes
Packard Center for ALS Research
institution · KG edge: regulates
HDAC2 Gene
gene · KG edge: regulates
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: activates

Knowledge Graph (12 edges)

KCNQ2 therapeutic_target SCN1A
KCNQ2 therapeutic_target MTOR
KCNQ2 therapeutic_target RELN
KCNQ2 regulates MECP2
KCNQ2 regulates HDAC2
KCNQ2 associated_with KCNT1
KCNQ2 therapeutic_target DHX9
KCNQ2 regulates HCRT
KCNQ2 activates EGFR
KCNQ2 regulates KCNQ3