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Home / Wiki / Entity: p62/SQSTM1 (Sequestosome-1)

entity 1,414 words KG: p62/SQSTM1 2026-03-22

kind:entity section:entities state:published

Contents

p62/SQSTM1 (Sequestosome-1)

Knowledge Graph

Related Hypotheses (8)

Conditional CRISPR Kill Switches for Aberrant Protein Cleara
Score: 0.45 APOE-Dependent Autophagy Restoration
Score: 0.61 Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59 Autophagosome Maturation Checkpoint Control
Score: 0.49 Lysosomal Membrane Repair Enhancement
Score: 0.45

Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.44 PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.42 VCP-Mediated Autophagy Enhancement
Score: 0.41

Related Analyses (6)

What determines the spatial organization of autophagy recept
neurodegeneration · failed APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Mitochondrial transfer between neurons and glia
neurodegeneration · archived

Related Experiments (11)

iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90 iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85 Resveratrol protection against renal I/R injury in diabetic
validation · proposed · Score: 0.90 Autophagy receptor identification for stress granule elimina
exploratory · proposed · Score: 0.90 Autophagy receptor knockout effects on stress granule accumu
exploratory · proposed · Score: 0.85

Resveratrol effects on HK-2 cells under hypoxia/reoxygenatio
exploratory · proposed · Score: 0.85 Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40 cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40 Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40 Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40 TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40

See Also (13)

NEMO/IKKγ Protein
protein · KG edge: co_localizes cGAS-STING Pathway Dysregulation Hypothesis in Parkinso
hypothesis · KG edge: activates OPTN — Optineurin
gene · KG edge: interacts_with NBR1 Gene
gene · KG edge: associated_with MYOT Gene
gene · KG edge: associated_with

MAP1LC3A Gene
gene · KG edge: binds HSPB1 — Heat Shock Protein Family B Member 1
gene · KG edge: regulates FLNC Gene
gene · KG edge: associated_with DNAJB6 Gene
gene · KG edge: associated_with DES Gene
gene · KG edge: co_discussed BRCA1 Gene
gene · KG edge: co_discussed Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates nf-kb
general · KG edge: regulates

Knowledge Graph (6 edges)

p62/SQSTM1 regulates autophagy

p62/SQSTM1 interacts_with LC3

p62/SQSTM1 binds LC3

LC3 interacts_with p62/SQSTM1

NF-kB regulates p62/SQSTM1

NEMO co_localizes p62/SQSTM1

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