gene 1,404 words KG: HSP27 2026-03-28
kind:genesection:genesstate:published
Contents

HSPB1 — Heat Shock Protein Family B Member 1

🧬 Gene Info
Gene SymbolHSPB1
Full NameHeat Shock Protein Family B Member 1
AliasesHsp27
Chromosome7q11.23.
Molecular Weight27 kDa
Amino Acids205 aa
PathwaysMAPK Pathway, NF-κB, PI3K
GeneCardsHSPB1
Human Protein AtlasHSPB1
Basal state16-24 subunit oligomers
Stressed stateSmaller oligomers (8-12 mers) with increased chaperone activity
Phosphorylated stateDisassembly to dimers/tetramers
Associated DiseasesAging, Als, Alzheimer, Cardiovascular, Ms, Multiple Sclerosis
InteractionsALS, CH25H, ATF3, VIM, NEURODEGENERATION, CANCER
SciDEX HypothesesHSPB1 Phosphorylation Mimetics to Promote Protecti
KG Connections323 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (11)

HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43
Score: 0.60
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Microbial Inflammasome Priming Prevention
Score: 0.58

Related Analyses (7)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (14)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: protects_against
Alzheimer Indonesia
institution · KG edge: inhibits
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibits
CFTR Gene
gene · KG edge: regulates
C1QB — Complement Component 1Q Beta
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

HSP27 phosphorylates P62
HSP27 activates P62
HSP27 regulates SQSTM1
HSP27 regulates AKT
HSP27 regulates UBIQUITIN
HSP27 co_discussed HSP70
HSP27 treats HSP70
HSP27 regulates PI3K
HSP27 regulates HSF1
HSP27 regulates HSP70