gene 1,401 words KG: OPTN 2026-03-24
kind:genesection:genesstate:published
Contents

OPTN — Optineurin

🧬 Gene Info
Gene SymbolOPTN
Full NameOptineurin
Chromosome10p13
Protein TypeAdaptor Protein
Functionis a 66 kDa coiled-coil domain-containing protein encoded by the OPTN gene on chromosome 10p13.
Primary ExpressionMotor cortex, Spinal cord, Retina, Brain
Molecular Weight66 kDa
Amino Acids577 aa
PathwaysAkt, Amyloid, Apoptosis, Autophagy, Immune Response
UniProt IDQ96CV9
NCBI Gene ID10133
Ensembl IDENSG00000123240
OMIM602432
GeneCardsOPTN
Human Protein AtlasOPTN
Associated DiseasesAD, ALI, ALS, AMI, AUTOPHAGY, AXONAL DEGENERATION
Known Drugs/CompoundsDEFERIPRONE, RAPAMYCIN, dimethyl fumarate, rapamycin, loganin
InteractionsRIPK1, ULK1, SMCR8, CALCOCO2, LC3, BECN1
KG Connections2510 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (26)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Transcriptional Autophagy-Lysosome Coupling
Score: 0.68
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (5)

Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri
clinical · proposed · Score: 0.40
Brainstem Circuit Modulation for PSP
clinical · proposed · Score: 0.40
Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
CBS vs PSP Phenotype Determinants — Single-Nucleus Multi-Omi
validation · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40

See Also (10)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
AKT1 Gene
gene · KG edge: interacts_with
AIF1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

OPTN co_discussed P62
OPTN co_discussed RIPK1
OPTN co_discussed RIPK3
OPTN mediates LC3
OPTN binds_to UBIQUITIN
OPTN associated_with VESICLE_TRAFFICKING
OPTN protects_against AXONAL_DEGENERATION
OPTN activates SMCR8
OPTN activates TOLLIP
OPTN activates PARL