| Gene Symbol | DNAJB6 |
| Chromosome | 7p12.3 |
| Protein Type | Chaperone |
| Target Class | Protein |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Mechanism of Action | Prioritized from 1 SciDEX hypotheses, including: HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor |
| Primary Expression | Broad, high in muscle and brain |
| Druggability | Undruggable (0.23) |
| Molecular Weight | 38 kDa |
| Amino Acids | 326 aa |
| Pathways | proteostasis |
| UniProt ID | O75146 |
| GeneCards | DNAJB6 |
| Human Protein Atlas | DNAJB6 |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Dementia |
| Known Drugs/Compounds | amyloid-beta 42 |
| Interactions | Actin, alpha-synuclein, Alpha-Synuclein, ALPHA-SYNUCLEIN, ALS, ALZHEIMER |
| SciDEX Target | View Target Profile |
| SciDEX Hypotheses | J-protein substrate specificity codes enable HSP70 HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Distinct J-protein architectures decode exposed β- |
| KG Connections | 456 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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