protein 720 words KG: LC3 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

LC3 Protein

🔬 Protein Info
Gene SymbolLC3
AliasesMicrotubule-Associated Protein 1 Light Chain 3
Protein TypeTranscription Factor
FunctionLC3 is essential for autophagosome formation and function
Subcellular Localization</th><td>Cytoplasm, autophagosome membrane</td></tr>
Molecular Weight17 kDa
PathwaysAkt, Apoptosis, Autophagy, Camp Signaling, Cell Cycle
GeneCardsLC3
Human Protein AtlasLC3
Associated DiseasesAD, ALI, ALS, AMI, ARM, Aging
Known Drugs/CompoundsRAPAMYCIN, nicotinamide, statins, dimethyl fumarate, CISPLATIN, rapamycin
InteractionsMTOR, ABCG1, SQSTM1, ABCA1, APOE, LOX
KG Connections3286 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65

Related Analyses (21)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (21)

iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90
CLOCK/BMAL1 regulation of ICC autophagy in GERD model
exploratory · proposed · Score: 0.90
P2RY12 regulation of autophagy in VSMCs
exploratory · proposed · Score: 0.90
iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40

See Also (5)

ACLY Inhibition Rescues Alpha-Synuclein Autophagy
mechanism · KG edge: activates
ACTB Gene
gene · KG edge: activates
ABCG1 Gene
gene · KG edge: activates
ABCD3 Gene
gene · KG edge: activates
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: activates

Knowledge Graph (12 edges)

LC3 associated_with APOE
LC3 associated_with BCL2
LC3 associated_with PINK1
LC3 associated_with STAT3
LC3 associated_with JUN
LC3 associated_with NRF2
LC3 co_discussed P2RY12
LC3 co_discussed SQSTM1
LC3 co_discussed P62
LC3 co_discussed ULK1