| Gene Symbol | DES |
| Full Name | Desmin |
| Chromosome | 2q35 |
| Function | is a critical structural component of muscle cells[@paulin2004]. |
| Molecular Weight | 53 kDa |
| Amino Acids | 470 aa |
| Pathways | Angiogenesis, Apoptosis, Autophagy, Ferroptosis, Necroptosis |
| UniProt ID | P17661 |
| NCBI Gene ID | 1674 |
| Ensembl ID | ENSG00000175084 |
| OMIM | 125660 |
| GeneCards | DES |
| Human Protein Atlas | DES |
| N-terminal head domain (residues 1-99) | Contains phosphorylation sites and regulates filament assembly |
| Central rod domain (residues 100-411) | Consists of four alpha-helical segments (1A, 1B, 2A, 2B) separated by linkers, responsible for dimerization and filament assembly |
| Associated Diseases | Aging, Als, Alzheimer, Cancer, Cardiac, Cardiovascular |
| Interactions | MCU, BECN1, SLC7A11, RIPK1, FADD, NRP1 |
| KG Connections | 199 knowledge graph edges |
| Databases | GeneCardsHPASTRING |